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AB47352

Human Syndecan-1 ELISA Set (without plates)

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(5 Publications)

Human Syndecan-1 ELISA Set (without plates) is a Sandwich (quantitative) ELISA for the measurement of Human Syndecan-1 ELISA Set (without plates) in Human in Biofluids, Cell Culture Media samples.

View Alternative Names

CD138, SDC, SDC1, Syndecan-1, SYND1

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Sandwich ELISA - Human Syndecan-1 ELISA Set (without plates) (AB47352)
  • sELISA

Supplier Data

Sandwich ELISA - Human Syndecan-1 ELISA Set (without plates) (AB47352)

Syndecans standard curve ranging from 8 to 256 ng/ml

Key facts

Sample types

Plasma, Cell culture supernatant, Serum

Reacts with

Human

Assay type

Sandwich (quantitative)

Sensitivity

< 4.94 ng/mL

Range

8 - 256 ng/mL

Assay time

1h 45m

Assay Platform

Reagents

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "sELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Abcam's Syndecan-1 Human in vitro ELISA Set is designed for the quantitative measurement of Syndecan-1 in cell culture supernatants, buffered solutions, serum, plasma and other body fluids.

This ELISA Set is intended to measure human Syndecan-1 in cell -culture supernatants, as well as in serum and plasma samples. The enclosed procedures provide general guidelines for ELISA preparation. This procedure may need some optimization depending on the plastic, matrix, standard range.

The Syndecan-1 ELISA Set includes both the capture and the detection antibodies as well as Horse-Radish peroxidase conjugated Streptavidin (HRP-Strep) and TMB which are the reagents used in the colour development step.

Recognizes both natural and recombinant human Syndecan-1.

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What's included?

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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Syndecan-1 also known as CD138 is a transmembrane heparan sulfate proteoglycan with a molecular weight of approximately 30 to 80 kDa. The size variation arises from differences in its glycosaminoglycan chains. This protein resides predominantly on the surface of epithelial cells and plasma cells. Researchers commonly use the CD138 marker to identify these cells in biological samples. It plays a significant role in cell-cell and cell-matrix interactions acting as a co-receptor for a variety of growth factors cytokines and extracellular matrix proteins.
Biological function summary

Syndecan-1 participates in tissue repair inflammation and cell signaling ensuring epithelial integrity and communication. Syndecan-1 influences cell behavior by interacting with other components of the extracellular matrix and different membrane receptors. It is also involved in forming and regulating proteoglycan complexes at the cell surface. These complex interactions facilitate the modulation of cell proliferation migration and differentiation which are fundamental to maintaining tissue architecture and function.

Pathways

Syndecan-1 actively contributes to both the Wnt and FGF signaling pathways. Through its interaction with proteins such as miR-15 syndecan-1 modulates cellular responses essential for developmental processes and tissue homeostasis. The connection with these pathways allows syndecan-1 to integrate and relay extracellular signals impacting gene expression and cellular behavior. Its relationship with other proteins like A38 as a co-receptor emphasizes its role in finely tuning signaling cascades within cellular environments.

Syndecan-1 shows a connection to multiple myeloma and breast cancer. The overexpression of syndecan-1 in these conditions disrupts normal cellular functions and promotes tumorigenesis by aiding in the tumor cell's adhesion migration and invasion. Its interaction with proteins such as perCP further demonstrates its role in disease progression providing potential as a therapeutic target. These relationships make syndecan-1 an important focus for research in oncology and other fields of disease study.
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Product protocols

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Target data

The protein expressed by the SDC1 gene is a cell surface proteoglycan with heparan sulfate and chondroitin sulfate, linking the cytoskeleton to the interstitial matrix. It regulates exosome biogenesis alongside SDCBP and PDCD6IP. This supplementary information is collated from multiple sources and compiled automatically.
See full target information SDC1
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Toxicon: X 26:100226 PubMed40525140

2025

Pathophysiological role of endothelial biomarkers in sp. venom-induced renal dysfunction and the therapeutic effect of antivenom.

Applications

Unspecified application

Species

Unspecified reactive species

Nicole Coelho Lopes,Gdayllon Cavalcante Meneses,Ranieri Sales de Souza Santos,Leticia Machado de Araújo,Bruna Viana Barroso Martins,Katarina Maria Dos Reis Araújo,Valéria Holanda Nogueira de Aquino,Igor Moreira de Almeida,Sandra Mara Brasileiro Mota,Geraldo Bezerra da Silva Junior,Camila Eleuterio Rodrigues,Elizabeth De Francesco Daher,Polianna Lemos Moura Moreira Albuquerque,Alice Maria Costa Martins

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 56:e12728 PubMed37585916

2023

Predictors of mortality in critically ill patients with COVID-19 and diabetes.

Applications

Unspecified application

Species

Unspecified reactive species

A P P Lázaro,M S Zaranza,G C Meneses,N L Aragão,M V P Freire,Á R Guimarães,A M Beliero,M M P Dantas,L C Forte,A M C Martins,E F Daher,P L M M Albuquerque,G B da Silva Júnior

Tropical medicine & international health : TM & IH 27:727-734 PubMed35761507

2022

Endothelial biomarkers as predictors for haemodialysis need in severe leptospirosis patients (Weil's disease).

Applications

Unspecified application

Species

Unspecified reactive species

Gdayllon Cavalcante Meneses,Pedro Eduardo Andrade de Carvalho Gomes,Gabriela Studart Galdino,Gabriela Freire Bezerra,Ranieri Sales de Souza Santos,Alice Maria Costa Martins,Geraldo Bezerra da Silva Junior,Alexandre Braga Libório,Roberto da Justa Pires Neto,Elizabeth De Francesco Daher

Nature communications 12:3543 PubMed34112803

2021

Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution.

Applications

Unspecified application

Species

Unspecified reactive species

Luize G Lima,Sunyoung Ham,Hyunku Shin,Edna P Z Chai,Erica S H Lek,Richard J Lobb,Alexandra F Müller,Suresh Mathivanan,Belinda Yeo,Yeonho Choi,Belinda S Parker,Andreas Möller

Cancers 11: PubMed31443604

2019

L19-IL2 Immunocytokine in Combination with the Anti-Syndecan-1 46F2SIP Antibody Format: A New Targeted Treatment Approach in an Ovarian Carcinoma Model.

Applications

Unspecified application

Species

Unspecified reactive species

Paola Orecchia,Enrica Balza,Gabriella Pietra,Romana Conte,Nicolò Bizzarri,Simone Ferrero,Maria Cristina Mingari,Barbara Carnemolla
View all publications
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