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AB178649

Anti-Malaria ELISA Kit

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Anti-Malaria ELISA Kit is an indirect ELISA for the qualitative detection of class antibodies against Malaria ELISA Kit in human plasma and serum samples.

- Colorimetric readout - 450 nm - Works on any standard plate reader
- Easy results interpretation

Key facts

Detection method

Colorimetric

Sample types

Citrate plasma, Heparin Plasma, Serum

Reacts with

Human

Assay type

Indirect

Sensitivity

= 95.9 %

Assay Platform

Microplate

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Abcam's anti-Malaria Human in vitro ELISA (Enzyme-Linked Immunosorbent Assay) kit is designed for the accurate qualitative measurement of IgG and IgM class antibodies against Malaria in Human serum and plasma.

A 96-well plate has been precoated with Malaria antigens to bind cognate antibodies. Controls or test samples are added to the wells and incubated. Following washing, a horseradish peroxidase (HRP) labelled anti-Human IgG and anti-Human IgM conjugate is added to the wells, which binds to the immobilized Malaria antigens. TMB is then catalyzed by the HRP to produce a blue color product that changes to yellow after adding an acidic stop solution. The intensity of yellow coloration is directly proportional to the amount of Malaria IgG or Malaria IgM sample captured in plate.

REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.

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Precision

[ { "reproducibilityType": "Inter", "sample": "Negative", "replicates": 24, "mean": null, "standardDeviation": null, "coefficientOfVariability": "10.3" }, { "reproducibilityType": "Inter", "sample": "Positive Sample", "replicates": 24, "mean": null, "standardDeviation": null, "coefficientOfVariability": "3.2" }, { "reproducibilityType": "Inter", "sample": "Positive Sample", "replicates": 24, "mean": null, "standardDeviation": null, "coefficientOfVariability": "4.8" }, { "reproducibilityType": "Intra", "sample": "Negative", "replicates": 22, "mean": null, "standardDeviation": null, "coefficientOfVariability": "5.5" }, { "reproducibilityType": "Intra", "sample": "Positive Sample", "replicates": 22, "mean": null, "standardDeviation": null, "coefficientOfVariability": "2.8" }, { "reproducibilityType": "Intra", "sample": "Positive Sample", "replicates": 22, "mean": null, "standardDeviation": null, "coefficientOfVariability": "3.9" } ]
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What's included?

{ "values": { "1x96Tests": { "sellingSize": "1 x 96 Tests", "publicAssetCode":"ab178649-1x96Tests", "assetComponentDetails": [ { "size":"1 x 20 mL", "name":"Malaria Anti-IgG and Anti-IgM HRP Conjugate", "number":"AB178649-CMP07", "productcode":"" }, { "size":"1 x 2 mL", "name":"Malaria Positive Control", "number":"AB178649-CMP09", "productcode":"" }, { "size":"1 x 2 mL", "name":"Malaria Negative Control", "number":"AB178649-CMP08", "productcode":"" }, { "size":"1 x 3 mL", "name":"Malaria Cut-off Control", "number":"AB178649-CMP06", "productcode":"" }, { "size":"1 x 100 mL", "name":"IgG Sample Diluent", "number":"AB178649-CMP02", "productcode":"" }, { "size":"1 x 50 mL", "name":"20X Washing Solution", "number":"AB178649-CMP04", "productcode":"" }, { "size":"1 x 15 mL", "name":"Stop Solution", "number":"AB178649-CMP10", "productcode":"" }, { "size":"1 x 15 mL", "name":"TMB Substrate Solution", "number":"AB178649-CMP03", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Malaria Coated Microplate (12 x 8 wells)", "number":"AB178649-CMP05", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Strip holder", "number":"AB178649-CMP11", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Cover Foil", "number":"AB178649-CMP01", "productcode":"" } ] } } }
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Anti-malaria antibodies also known as antimalarial antibodies function by targeting specific proteins associated with the malaria parasite. These antibodies recognize and bind to proteins expressed on the surface of Plasmodium species which are responsible for causing malaria. These target proteins often include merozoite surface proteins which have an essential role in the parasite's life cycle. The molecular weight of these surface proteins can vary but many fall within a range typical for membrane proteins. These targets are expressed predominantly within infected red blood cells as well as the liver cells during the parasite's development stages.
Biological function summary

These antibodies play an important role in the immune response neutralizing malaria parasites and inhibiting their replication. They form part of a larger immune system complex that activates other immune cells to destroy the infected host cells. Anti-malaria ELISA assays including the ELISA malaria kit often test for these antibodies to assess immune response in patients. Such assays help in determining prior exposure to malaria and can guide treatment efforts. The presence of these antibodies serves as evidence of the body's attempt to control or eliminate the parasite.

Pathways

A specific interaction between anti-malaria antibodies and the malaria parasite surface proteins disrupts key pathways necessary for the parasite's survival and replication. These proteins are part of invasive pathways including the erythrocyte invasion pathway involving proteins like AMA1 and MSP1. These antibodies interfere with these pathways aiding in the prevention of successful parasite invasion and maturation within host cells. The disruption of these pathways limits the malaria parasite's ability to multiply and spread thereby providing an important checkpoint in malaria pathogenesis.

Anti-malaria antibodies are directly connected to their protective role against malaria infection and its complications such as cerebral malaria and anemia. Individuals with higher levels of these antibodies often demonstrate increased resistance to severe forms of the disease. The antibodies can also serve in conjunction with proteins involved in immune regulation like cytokines which further modulate the body's response to infection. Researchers and healthcare professionals utilize malaria test kits to detect these antibodies allowing for early diagnosis and intervention to reduce malaria's impact on affected populations.
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Product protocols

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Target data

See full target information Anti-Malaria antibodies
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websiteProtocolBooklet
en
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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