Mouse GREM2 ELISA kit (PDRC)

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

PRDC also known as protein related to DAN and cerberus or GREM2 is a member of the DAN family of cysteine knot secreted proteins. It weighs approximately 24 kDa. PRDC expresses in various tissues with strong presence in the heart lung and kidney among others. Its expression pattern suggests a role in organ development and tissue homeostasis. As a secreted protein PRDC exists outside the cell where it can interact with other molecules in the extracellular environment.

Biological function summary

PRDC functions as an antagonist of bone morphogenetic proteins (BMPs) which are part of the TGF-beta superfamily. By inhibiting BMP signaling PRDC regulates cell differentiation and growth. This protein does not work alone; it often interacts within larger complexes that involve other members of the BMP family. Through this interaction PRDC plays a role in developmental processes and tissue regeneration.

Pathways

PRDC integrates into key signaling cascades such as the BMP signaling pathway and TGF-beta pathway. It modulates the activity of BMPs directly affecting SMAD-dependent signaling. This role places it as a critical player in embryogenesis and organogenesis. Proteins like noggin and chordin also intersect with PRDC within these pathways working together to modulate cellular responses.

Associated diseases and disorders

Altered PRDC function links to various conditions including fibrodysplasia ossificans progressiva (FOP) and pulmonary hypertension. These diseases highlight the importance of proper BMP signaling modulation by PRDC. In the context of FOP abnormal PRDC expression can exacerbate processes like heterotopic ossification. Proteins such as ACVR1 involved in BMP signaling exhibit interconnected roles with PRDC in these pathological conditions.