Mouse Prorenin + renin ELISA kit

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Renin and prorenin are aspartyl proteases known for their role in the renin-angiotensin system. Renin sometimes referred to as angiotensinogenase has a molecular mass of approximately 37 kDa. Prorenin the precursor form of renin is slightly heavier with a mass around 46 kDa. These proteins are typically expressed in the juxtaglomerular cells of the kidney where renin converts angiotensinogen to angiotensin I an essential step in blood pressure regulation.

Biological function summary

Renin and prorenin play significant roles in regulating blood pressure and electrolyte balance. Renin is not part of a larger complex but acts as an important enzyme initiating the cascade that leads to angiotensin II production. Angiotensin II is a potent vasoconstrictor and stimulates aldosterone release. This mechanism is central to maintaining vascular tone and sodium homeostasis impacting both cardiac function and fluid-electrolyte balance.

Pathways

Renin and prorenin are central to the renin-angiotensin system a critical pathway for cardiovascular homeostasis. They interact closely with angiotensinogen and subsequently influence angiotensin I processing. Moreover the pathway links to the kallikrein-kinin system affecting bradykinin levels and therefore modulating inflammatory responses. This interconnectedness demonstrates the importance of renin and prorenin in maintaining homeostasis and responding to physiological changes.

Associated diseases and disorders

Renin and prorenin are implicated in conditions such as hypertension and heart failure. Abnormal activity or regulation of these proteins can lead to sustained elevation of blood pressure. In these contexts they often interact with angiotensin-converting enzyme (ACE) as elevated angiotensin II influences the pathology of these diseases. Understanding their role facilitates the development of inhibitors and blockers targeting this pathway to treat these cardiovascular disorders effectively.