Anti-Natalizumab ELISA Kit

Product details

Note: Anti-Natalizumab ELISA kit ab282909 is intended for Research Use Only, not for use in diagnostic procedures

Anti-Natalizumab ELISA kit is a sandwich ELISA assay for the qualitative detection of antibody against Natalizumab with high specificity and sensitivity in serum and plasma samples. Controls and samples are incubated in the microtiter plate coated with the drug Natalizumab. After incubation, the wells are washed. Then, HRP conjugated probe is added and binds to Natalizumab antibodies captured by the drug Natalizumab on the surface of the wells. Following incubation wells are washed and the bound enzymatic activity is detected by addition of chromogen-substrate. Finally, the reaction is terminated with an acidic stop solution. The color developed is proportional to the amount of Natalizumab antibodies in the sample or controls. The results can be evaluated with using cut-off value.

Cross Reactivity: Natalizumab infusion camouflages/masks the presence of antibody to Natalizumab in serum/plasma samples. Therefore, blood sampling time is critical for detection of anti-drug-antibodies. It is convenient to obtain blood sample just before the infusion or at least 2 weeks after the infusion of Natalizumab.

This product is manufactured by BioVision, an Abcam company and was previously called E4857 BioSim™ anti-Natalizumab (Tysabri®) (Human) ELISA Kit. E4857-100 is the same size as the 1 x 96 tests size of ab282909.