Anti-Rheumatoid Factor IgM ELISA Kit

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Rheumatoid Factor IgM often referred to as IgM RF is an autoantibody that targets the Fc region of IgG immunoglobulins. It is primarily expressed in synovial fluid and blood plasma. The mass of the IgM RF antibody typically ranges between 970-1000 kDa. Its main role involves forming immune complexes by binding to IgG contributing to inflammation and tissue damage in autoimmune conditions.

Biological function summary

The role of Rheumatoid Factor IgM involves mediating immune responses by participating in the formation of antigen-antibody complexes. Although it is not a part of a complex by itself IgM RF can interact with other components of the immune system to exacerbate inflammatory reactions. A characteristic feature is its involvement in the activation of the complement system which plays a part in promoting inflammation and autoimmune processes.

Pathways

Rheumatoid Factor IgM influences processes in the complement cascade and the immune response pathway. It interacts with components such as C-reactive protein and immunoglobulin G both involved in the regulation of inflammatory responses. The activities of IgM RF within these pathways contribute to the enhancement and maintenance of chronic inflammation seen in certain autoimmune conditions.

Associated diseases and disorders

Rheumatoid Factor IgM is most notably associated with rheumatoid arthritis and Sjögren's syndrome. It often correlates with disease severity and progression in rheumatoid arthritis by forming immune complexes that contribute to chronic joint inflammation and damage. In Sjögren's syndrome IgM RF along with anti-SS-A/Ro antibodies plays a role in the pathogenesis and facilitates glandular dysfunction and dryness. Its presence helps in diagnosis and prognosis of these diseases making it a significant biomarker in autoimmune disease management.