Streptomycin ELISA Kit

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Streptomycin is an aminoglycoside antibiotic with a molecular mass of approximately 581.6 Daltons. It is produced by the bacterium Streptomyces griseus. Streptomycin works by targeting the bacterial ribosome specifically the 16S rRNA component of the 30S subunit. This interaction disrupts protein synthesis leading to the misreading of mRNA which ultimately affects bacterial growth and viability. Its production ability is maximized in specific environmental conditions favorable for the Streptomyces species.

Biological function summary

Streptomycin plays a role in inhibiting bacterial protein synthesis making it effective against a variety of bacterial infections. It is not part of a larger complex but requires the presence of ATP for uptake by bacteria. Once inside streptomycin binds to the ribosomal subunit altering the codon-anticodon recognition site. This binding action interrupts normal bacterial functions and helps in the eradication of infections. Its spectrum of activity includes both gram-positive and gram-negative bacteria though it is more potent against aerobic bacteria.

Pathways

The mechanism of streptomycin intersects with the bacterial translational machinery pathways targeting ribosomal pathways leading to protein synthesis inhibition. It shares a connection with other aminoglycosides like gentamicin and kanamycin which also disrupt protein synthesis at the ribosome level. The disruption of these pathways halts bacterial growth therefore streptomycin and related drugs are utilized in various antibiotic treatments.

Associated diseases and disorders

Streptomycin proves effective against tuberculosis and certain types of enterococcal infections. It is commonly used in combination with other antibiotics such as isoniazid or rifampicin for treating tuberculosis to reduce resistance development. Streptomycin's association with these antibiotics enhances its effectiveness and helps combat the pathological effects caused by resistant strains. Its use in treatment regimens highlights its importance in managing and treating communicable bacterial diseases.