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AB285226

Streptomycin ELISA Kit

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Streptomycin ELISA Kit is a Competitive ELISA for the measurement of Streptomycin in in Cell/Tissue Extracts, Biofluids samples.
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Competitive ELISA - Streptomycin ELISA Kit (AB285226)
  • cELISA

Supplier Data

Competitive ELISA - Streptomycin ELISA Kit (AB285226)

Streptomycin ELISA Kit.

Typical Standard Curve : These standard curves are for demonstration only. A standard curve must be run with each assay.

Key facts

Detection method

Colorimetric

Sample types

Tissue, Milk

Assay type

Competitive

Sensitivity

< 0.1 ng/mL

Range

0.1 - 8.1 ng/mL

Assay Platform

Microplate (12 x 8 well strips)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "cELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Streptomycin is an antibiotic (antimycobacterial) drug, the first of a class of drugs called aminoglycosides to be discovered, and it was the first effective treatment for tuberculosis. It is derived from the actinobacterium Streptomyces griseus. Streptomycin is a bactericidal antibiotic. Adverse effects of this medicine are ototoxicity, nephrotoxicity, fetal auditory toxicity, and neuromuscular paralysis.

This Streptomycin ELISA kit (ab285226, E4272) is a competitive ELISA assay for the quantitative measurement of Streptomycin in tissue, honey and milk. The density of color is proportional to the amount of Streptomycin captured from the samples.

This product is manufactured by BioVision, an Abcam company and was previously called E4272 Streptomycin ELISA Kit. E4272-100 is the same size as the 96 test size of ab285226.

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What's included?

{ "values": { "96Test": { "sellingSize": "96 Test", "publicAssetCode":"ab285226-96Test", "assetComponentDetails": [ { "size":"1 x 50 mL", "name":"5X Concentrated Redissolving solution", "number":"AB285226-CMP04", "productcode":"" }, { "size":"1 x 6 mL", "name":"Substrate B solution", "number":"AB285226-CMP11", "productcode":"" }, { "size":"1 x 1 mL", "name":"Standard 6 (8.1 ppb)", "number":"AB285226-CMP17", "productcode":"" }, { "size":"1 x 1 mL", "name":"Standard 5 (2.7 ppb)", "number":"AB285226-CMP16", "productcode":"" }, { "size":"1 x 1 mL", "name":"Standard 4 (0.9 ppb)", "number":"AB285226-CMP15", "productcode":"" }, { "size":"1 x 1 mL", "name":"Standard 3 (0.3 ppb)", "number":"AB285226-CMP14", "productcode":"" }, { "size":"1 x 1 mL", "name":"Standard 2 (0.1 ppb)", "number":"AB285226-CMP13", "productcode":"" }, { "size":"1 x 1 mL", "name":"Standard 1 (0 ppb)", "number":"AB285226-CMP12", "productcode":"" }, { "size":"1 x 5.5 mL", "name":"Antibody working solution", "number":"AB285226-CMP01", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Plate Sealer", "number":"AB285226-CMP08", "productcode":"" }, { "size":"1 x 1 mL", "name":"High standard (1000 ppb)", "number":"AB285226-CMP02", "productcode":"" }, { "size":"1 x 6 mL", "name":"Stop Solution", "number":"AB285226-CMP09", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Micro ELISA Plate", "number":"AB285226-CMP07", "productcode":"" }, { "size":"1 x 11 mL", "name":"Enzyme conjugate", "number":"AB285226-CMP03", "productcode":"" }, { "size":"1 x 6 mL", "name":"Substrate A solution", "number":"AB285226-CMP10", "productcode":"" }, { "size":"1 x 40 mL", "name":"20X Concentrated Wash Solution", "number":"AB285226-CMP05", "productcode":"" } ] } } }
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Streptomycin is an aminoglycoside antibiotic with a molecular mass of approximately 581.6 Daltons. It is produced by the bacterium Streptomyces griseus. Streptomycin works by targeting the bacterial ribosome specifically the 16S rRNA component of the 30S subunit. This interaction disrupts protein synthesis leading to the misreading of mRNA which ultimately affects bacterial growth and viability. Its production ability is maximized in specific environmental conditions favorable for the Streptomyces species.
Biological function summary

Streptomycin plays a role in inhibiting bacterial protein synthesis making it effective against a variety of bacterial infections. It is not part of a larger complex but requires the presence of ATP for uptake by bacteria. Once inside streptomycin binds to the ribosomal subunit altering the codon-anticodon recognition site. This binding action interrupts normal bacterial functions and helps in the eradication of infections. Its spectrum of activity includes both gram-positive and gram-negative bacteria though it is more potent against aerobic bacteria.

Pathways

The mechanism of streptomycin intersects with the bacterial translational machinery pathways targeting ribosomal pathways leading to protein synthesis inhibition. It shares a connection with other aminoglycosides like gentamicin and kanamycin which also disrupt protein synthesis at the ribosome level. The disruption of these pathways halts bacterial growth therefore streptomycin and related drugs are utilized in various antibiotic treatments.

Streptomycin proves effective against tuberculosis and certain types of enterococcal infections. It is commonly used in combination with other antibiotics such as isoniazid or rifampicin for treating tuberculosis to reduce resistance development. Streptomycin's association with these antibiotics enhances its effectiveness and helps combat the pathological effects caused by resistant strains. Its use in treatment regimens highlights its importance in managing and treating communicable bacterial diseases.
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Product protocols

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Target data

See full target information Streptomycin
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websiteProtocolBooklet
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