VILIP1 ELISA Kit is a single-wash 90-min SimpleStep ELISA® for the quantitative measurement of VILIP1 in Serum, Cerebral Spinal Fluid samples.
Colorimetric
Serum, Cerebral Spinal Fluid
Sandwich (quantitative)
Cow, Human
39.063 - 2500 pg/mL
1h 30m
= 18.144 pg/mL
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application sELISA | Reactivity Reacts | Dilution info - | Notes - |
Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.
VISL1, VSNL1, Visinin-like protein 1, VILIP, VLP-1, Hippocalcin-like protein 3, HLP3
VILIP1 ELISA Kit is a single-wash 90-min SimpleStep ELISA® for the quantitative measurement of VILIP1 in Serum, Cerebral Spinal Fluid samples.
Colorimetric
Serum, Cerebral Spinal Fluid
Sandwich (quantitative)
Cow, Human
39.063 - 2500 pg/mL
1h 30m
Pre-coated microplate (12 x 8 well strips)
= 18.144 pg/mL
Sample | n | mean | SD | C.V. |
---|---|---|---|---|
Sample Serum | n 8 | mean - | SD - | C.V. 6.7 |
Sample | n | mean | SD | C.V. |
---|---|---|---|---|
Sample Serum | n 3 | mean - | SD - | C.V. 14.7 |
Sample type | Average % | Range |
---|---|---|
Sample type Cerebral Spinal Fluid | Average % = 99 | Range 93 - 103 % |
Sample type Serum | Average % = 82 | Range 80 - 83 % |
Blue Ice
+4°C
+4°C
+4°C
This supplementary information is collated from multiple sources and compiled automatically.
Visinin-like protein 1 commonly abbreviated as VILIP1 is a neuronal calcium sensor protein. It has a mass of about 22 kDa and consists of four EF-hand motifs that bind calcium ions. VILIP1 is primarily expressed in the central nervous system including regions such as the hippocampus and cerebral cortex. This protein interacts with membranes and other intracellular molecular targets in response to changes in calcium levels influencing cellular activities associated with calcium signaling.
Visinin-like protein 1 modulates various physiological processes within neurons. It regulates signal transduction pathways by mediating calcium-dependent interactions with other proteins. VILIP1 may be part of complexes with other signaling proteins that participate in neurotransmitter release and synaptic plasticity. Its ability to modulate the phosphorylation status of its binding partners can influence neuronal excitability and synaptic communication.
Various studies highlight how visinin-like protein 1 participates in critical signaling modules. This protein contributes to the regulation of the cAMP signaling pathway where it can affect the activation of adenylate cyclase. Moreover VILIP1 interacts with signaling pathways related to nicotinic acetylcholine receptors affecting the transmission of nerve impulses. It influences the dynamics between calcium signaling and cAMP affecting processes like learning and memory.
Visinin-like protein 1 relates significantly to neurodegenerative diseases. Research findings associate elevated VILIP1 levels with Alzheimer's disease where it can serve as a biomarker for disease progression. Furthermore it connects to Parkinson's disease given its role in neuronal calcium homeostasis a critical factor in disease pathology. In Alzheimer's disease VILIP1 levels can correlate with beta-amyloid plaque development and tau protein phosphorylation.
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Example of VILIP1 standard curve in Sample Diluent NS.
Example of VILIP1 standard curve. Background-subtracted data values (mean +/- SD) are graphed.
Interpolated concentrations of spiked VILIP1 in bovine cerebrospinal fluid (CSF) and human serum.
Recombinant VILIP1 was spiked into the following samples and diluted in a 2-fold dilution series in Sample Diluent NS. Undiluted samples are as follows: human serum 25% and bovine CSF 50%. The interpolated dilution factor corrected values are plotted (mean +/- SD, n=2).
Interpolated concentrations of native VILIP1 in bovine and human CSF.
Interpolated concentrations of native VILIP1 were measured in duplicate in 50% bovine and human CSF. The interpolated dilution factor corrected values are plotted (mean +/- SD, n=2). Sample dilutions are made in Sample Diluent NS.
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