JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB316782

Human CXCL17/DMC Antibody Pair - BSA and Azide free

Be the first to review this product! Submit a review

|

(0 Publication)

Human CXCL17/DMC Antibody Pair - BSA and Azide free is a kit containing recombinant capture and detector antibodies in a carrier-free formulation for the measurement of Human CXCL17/DMC.

View Alternative Names

VCC1, UNQ473/PRO842, CXCL17, C-X-C motif chemokine 17, 6-Cys CXCL17, Dendritic cell and monocyte chemokine-like protein, VEGF coregulated chemokine 1, DMC

1 Images
Sandwich ELISA - Human CXCL17/DMC Antibody Pair - BSA and Azide free (AB316782)
  • sELISA

Supplier Data

Sandwich ELISA - Human CXCL17/DMC Antibody Pair - BSA and Azide free (AB316782)

Sandwich ELISA of ab316782 with the capture antibody ab316783 dilution at 2 ug/mL and detector antibody ab316784 dilution at 0.5 ug/mL.

Key facts

Reacts with

Human

Assay type

ELISA set

Range

19.53 - 1250 pg/mL

Assay Platform

Reagents

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "sELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column

Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with <1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

The pair can be used in variety of assays and platforms including but not limited to:

  • Sandwich ELISA
  • FRET/TR-FRET/HTRF
  • Meso Scale Discovery® (MSD®)
  • Bead-based assays
  • AlphaLISA®/AlphaScreen®
  • DELFIA® immunoassays
  • Simoa® and Single Molecule Counting (SMC™) immunoassays
  • Multiplex

Our antibody pairs are supplied in a carrier-free format that is conjugation-ready:

  • Buffer free of BSA, sodium azide, and glycerol for higher conjugation efficiency.
  • Concentration of ~1 mg/ml as measured by the protein A280 method.

We can label antibodies for you: get in touch today to discuss how we can help accelerate your assay development with custom conjugation services.

Pairs are screened in biological samples, including plasma and serum, to ensure specificity in complex samples.

Please note:

The recommended antibody orientation is based on internal optimization in sandwich ELISA. Antibody orientation is assay dependent and needs to be optimized for each assay type.

The range provided for this antibody pair is based on initial sandwich ELISA validation data using recombinant protein. Performance and range of the antibody pair will depend on the specific characteristics of your assay, including standard protein selection.

We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibodies in other assays.

Antibody properties:

Capture antibody: recombinant rabbit monoclonal (unconjugated) – 100 µg

Detector antibody: recombinant rabbit monoclonal (unconjugated) - 100 µg

Concentration: ~1 mg/ml

Storage buffer: 100% PBS

Form: Liquid

Isotype: IgG

Recombinant monoclonal antibodies offer several advantages including:

- High batch-to-batch consistency and reproducibility

- Improved sensitivity and specificity

- Long-term security of supply

- Animal-free production

Meso Scale Discovery and MSD are registered trademarks of Meso Scale Diagnostics, LLC.

AlphaLISA, AlphaScreen, and DELFIA are registered trademarks of PerkinElmer, Inc.

Simoa is a registered trademark of Quanterix, Inc.

SMC is a registered trademark of Merck KGaA, Darmstadt, Germany.

style
left-column

What's included?

{ "values": { "10x96Tests": { "sellingSize": "10 x 96 Tests", "publicAssetCode":"ab316782-10x96Tests", "assetComponentDetails": [ { "size":"1 x 100 µg", "name":"Human CXCL17/DMC Detector Antibody (unconjugated)", "number":"AB316782-CMP02", "productcode":"AB316784" }, { "size":"1 x 100 µg", "name":"Human CXCL17/DMC Capture Antibody (unconjugated)", "number":"AB316782-CMP01", "productcode":"AB316783" } ] } } }
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
+4°C
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CXCL17 also known as DMC is a chemokine involved in immune cell recruitment. This protein has a molecular mass of about 17 kDa. Researchers found CXCL17 expressed in epithelial tissues including the respiratory tract and gastrointestinal tract. Its expression pattern indicates a role in mucosal immunity where it may attract immune cells to sites requiring defense against pathogens.
Biological function summary

CXCL17 functions to recruit monocytes and dendritic cells to regions where they are needed. It does not appear to form part of a larger protein complex. Its ability to attract specific immune cells suggests it has an important role in organizing immune responses particularly in tissues constantly exposed to external environmental factors. Additionally its presence in mucosal tissues supports the hypothesis that it might participate in the first line of defense against environmental pathogens.

Pathways

CXCL17 fits within the broader chemokine signaling pathways promoting cell migration and adhesion. This signaling integrates with inflammatory pathways such as the NF-kB pathway which regulates the expression of various other chemokines and cytokines. Researchers have noted relationships between CXCL17 and other chemokines like CXCL12 and CXCL8 indicating potential synergistic or regulatory interactions in immune response modulations.

CXCL17 associates with conditions like chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). These connections suggest a role for CXCL17 in chronic inflammatory and fibrotic pathologies of the lungs. In the context of these diseases the protein interacts with inflammatory mediators such as IL-6 contributing to the persistence and exacerbation of inflammation observed in these conditions. Understanding CXCL17's involvement in these diseases might aid in developing targeted therapies to modulate immune function and inflammation.
style
left-column

Product protocols

style
left-column

Target data

Chemokine that acts as a chemoattractant for monocytes, macrophages and dendritic cells (PubMed : 16455961, PubMed : 23115081). Plays a role in angiogenesis and possibly in the development of tumors (PubMed : 16989774, PubMed : 23115081). Acts as an anti-inflammatory in the stomach (PubMed : 23115081). May play a role in the innate defense against infections (PubMed : 17307946). Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed : 25411203).. 4-Cys CXCL17. Seems to exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.
See full target information CXCL17
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB316784

Anti-CXCL17/DMC antibody [EPR22655-87] - BSA and Azide free (Detector)

Recombinant|RabMAb

Sandwich ELISA - Anti-CXCL17/DMC antibody [EPR22655-87] - BSA and Azide free (Detector) (AB316784)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com