Human IL-1beta Matched Antibody Pair Kit is a kit for ELISA development for the measurement of Human IL-1beta by sandwich ELISA method.
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- Medicine 102:e323842023Effects of amlodipine combined with atorvastatin on Th17/Treg imbalance and vascular microcirculation in hypertensive patients with atherosclerosis: A double-blind, single-center randomized controlled trial.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGui Yang,Youjiang QiuPubMed 36820569
- Cytokine 153:1558682022Clinical monitored in subjects metabolically healthy and unhealthy before and during a SARS-CoV-2 infection- A cross-sectional study in Mexican population.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSamuel Treviño,Steffany Cortezano-Esteban,Hugo Hernández-Fragoso,Alfonso Díaz,Rubén Vázquez-Roque,Victor Enrique Sarmiento-Ortega,Diana Moroni-González,Rosana Pelayo,Eduardo BrambilaPubMed 35358903
- BMC pharmacology & toxicology 22:622021Famotidine promotes inflammation by triggering cell pyroptosis in gastric cancer cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJin Huang,Pingsheng Fan,Miao Liu,Chengtao Weng,Gaofei Fan,Tengyue Zhang,Xiaohong Duan,Yang Wu,Lili Tang,Guohong Yang,Yabei LiuPubMed 34686215
- Journal of cellular and molecular medicine 25:9983-99942021Dexmedetomidine alleviates hepatic ischaemia-reperfusion injury via the PI3K/AKT/Nrf2-NLRP3 pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYan Wu,Gaolin Qiu,Hainie Zhang,Leilei Zhu,Gao Cheng,Yiqiao Wang,Yuanhai Li,Weiwei WuPubMed 34664412
- Journal of inflammation research 14:4069-40772021The Relationship Between Circulating Bone Morphogenetic Protein-4 and Inflammation Cytokines in Patients Undergoing Thoracic Surgery: A Prospective Randomized Study.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXu Zhao,Jitao Zhang,Wenjuan Zhang,Ruping Dai,Junmei Xu,Zhijian Li,Lin YangPubMed 34456582
- BMC pharmacology & toxicology 22:442021Rabeprazole inhibits inflammatory reaction by inhibition of cell pyroptosis in gastric epithelial cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJing Xie,Long Fan,Liya Xiong,Peiyu Chen,Hongli Wang,Huan Chen,Junhong Zhao,Zhaohui Xu,Lanlan Geng,Wanfu Xu,Sitang GongPubMed 34266494
- Oxidative medicine and cellular longevity 2021:25806192021MicroRNA-145-Mediated KDM6A Downregulation Enhances Neural Repair after Spinal Cord Injury the NOTCH2/Abcb1a Axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChangzhao Gao,Fei Yin,Ran Li,Qing Ruan,Chunyang Meng,Kunchi Zhao,Qingsan ZhuPubMed 34122720
- Molecular medicine reports 23:2021IL-32 exacerbates adenoid hypertrophy via activating NLRP3-mediated cell pyroptosis, which promotes inflammation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJunmei Zhang et. al.PubMed 33495843
- Gastroenterology 157:1338-1351.e82019Infliximab-Tumor Necrosis Factor Complexes Elicit Formation of Anti-Drug Antibodies.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHaggai Bar-Yoseph et. al.PubMed 31401142
Key facts
- Detection method
- Colorimetric
- Assay type
- ELISA set
- Reactive species
- Human
- Range
- 31.25 - 2000 pg/mL
- Sensitivity
- = 12.9 pg/mL
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Potent pro-inflammatory cytokine (PubMed:10653850, PubMed:12794819, PubMed:28331908, PubMed:3920526). Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production (PubMed:3920526). Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6 (PubMed:12794819). Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33377178, PubMed:33883744). Acts as a sensor of S.pyogenes infection in skin: cleaved and activated by pyogenes SpeB protease, leading to an inflammatory response that prevents bacterial growth during invasive skin infection (PubMed:28331908).
Alternative names
IL1F2, IL1B, Interleukin-1 beta, IL-1 beta, Catabolin
What's included?
Recommended products
Human IL-1beta Matched Antibody Pair Kit is a kit for ELISA development for the measurement of Human IL-1beta by sandwich ELISA method.
Key facts
- Detection method
- Colorimetric
- Assay type
- ELISA set
- Reactive species
- Human
- Range
- 31.25 - 2000 pg/mL
- Assay Platform
- Reagents
- Sensitivity
- = 12.9 pg/mL
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- -20°C
Notes
Human IL-1beta Matched Antibody Pair Kits include a capture and a biotinylated detector antibody pair, along with a calibrated protein standard, suitable for sandwich ELISA. The Matched Antibody Pair Kit can be used to quantify native and recombinant human IL-1beta.Optimization of the kit reagents to sample type, immunoassay format or instrumentation may be required. Guidelines for use of this kit in a standard 96-well microplate sandwich ELISA using HRP/TMB system of colorimetric detection is described in this assay procedure for the purposes of quantification.Protocol information and tips on the use of the Matched Antibody Pair kits for sandwich ELISA can be found on our . An accessory pack can be purchased which includes buffer reagents required to perform 10 x 96-well plate sandwich ELISAs (ELISA Accessory Pack ab210905).For additional information on the performance of the antibody pair used in this kit, please see our equivalent SimpleStep ELISA kit Human IL-1 beta ELISA Kit ab214025. Please note that while the antibody pair is the same provided in the corresponding SimpleStep ELISA Kit, due to differences in their formulation, this antibody pair cannot be used with the consumables provided with our SimpleStep ELISA Kits.
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1 product image
ELISA - Human IL-1beta Matched Antibody Pair Kit (ab217608)
Human IL-1beta standard curve.
Standard calibration curve. Background subtracted values are graphed.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
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