AB241807

Human/Monkey IL-1beta Antibody Pair - BSA and Azide free

RabMAb
Recombinant
What is this?

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Human/Monkey IL-1beta Antibody Pair - BSA and Azide free is a kit containing recombinant capture and detector antibodies in a carrier-free formulation for the measurement of Human/Monkey IL-1beta.

View Alternative Names

IL1F2, IL1B, Interleukin-1 beta, IL-1 beta, Catabolin

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Sandwich ELISA - Human/Monkey IL-1beta Antibody Pair - BSA and Azide free (AB241807)

sELISA

Lab

Sandwich ELISA - Human/Monkey IL-1beta Antibody Pair - BSA and Azide free (AB241807)

Background subtracted standard curve using Human IL-1 beta Antibody Pair - BSA and Azide free (ab241807) and Recombinant human IL-1 beta protein (Active) (ab259387) in sandwich ELISA. The ELISA was performed using the components of the corresponding SimpleStep® kit, which uses the same antibody pair with a different formulation and format.

sELISA

Supplier Data

Sandwich ELISA - Human/Monkey IL-1beta Antibody Pair - BSA and Azide free (AB241807)

Representative standard curve from corresponding SimpleStep ELISA® Kit (ab214025), which uses the same antibody pair. For additional information on the performance of pair and kit, refer to the corresponding kit datasheet. Due to differences in the formulation and format of the antibodies in this pair, they cannot be used as substitutes for the antibody components in our SimpleStep ELISA® Kits.

sELISA

Supplier Data

Sandwich ELISA - Human/Monkey IL-1beta Antibody Pair - BSA and Azide free (AB241807)

Key facts

Reacts with

Human, Rhesus monkey, Cynomolgus monkey

Assay type

ELISA set

Range

31.25 - 2000 pg/mL

Assay Platform

Reagents

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "sELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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Product details

The Antibody Pair can be used to quantify Human/Monkey IL-1 beta. BSA and Azide free antibody pairs include unconjugated capture and detector antibodies suitable for sandwich ELISAs. The antibodies are provided at an approximate concentration of 1 mg/ml as measured by the protein A280 method. The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Both capture and detector antibodies are rabbit monoclonal antibodies delivering consistent, specific, and sensitive results. For additional information on the performance of the antibody pair, see the equivalent SimpleStep ELISA® Kit (ab214025), which uses the same antibodies. However, due to differences in their formulation, this antibody pair cannot be used with the consumables provided with our SimpleStep ELISA Kits. Please note that the range provided for the pairs is only an estimation based on the performance of the related product using the same antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody pair in your assay.

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What's included?

{ "values": { "10x96Tests": { "sellingSize": "10 x 96 Tests", "publicAssetCode":"ab241807-10x96Tests", "assetComponentDetails": [ { "size":"1 x 100 µg", "name":"Human/Monkey IL-1beta Capture Antibody (unconjugated)", "number":"AB241807-CMP01", "productcode":"" }, { "size":"1 x 100 µg", "name":"Human/Monkey IL-1beta Detector Antibody (unconjugated)", "number":"AB241807-CMP02", "productcode":"" } ] } } }

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Properties and storage information

Shipped at conditions

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Target data

Potent pro-inflammatory cytokine (PubMed : 10653850, PubMed : 12794819, PubMed : 28331908, PubMed : 3920526). Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production (PubMed : 3920526). Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed : 10653850). Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6 (PubMed : 12794819). Involved in transduction of inflammation downstream of pyroptosis : its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed : 33377178, PubMed : 33883744). Acts as a sensor of S.pyogenes infection in skin : cleaved and activated by pyogenes SpeB protease, leading to an inflammatory response that prevents bacterial growth during invasive skin infection (PubMed : 28331908).

See full target information IL1B

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

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