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AB233743

Anti-1, 3 beta glucan antibody [2G8]

3

(1 Review)

|

(11 Publications)

Anti-1, 3 beta glucan antibody [2G8] (ab233743) is a mouse monoclonal antibody detecting 1, 3 beta glucan in ELISA. Suitable for Aspergillus nidulans, Candida albicans.

- Recombinant format for unrivalled batch-batch consistency

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

2G8

Isotype

IgG2b

Carrier free

No

Reacts with

Aspergillus nidulans, Candida albicans

Applications

ELISA

applications

Specificity

ab233743 reacts with 1,3 Β- glucan from Candida albicans, Aspergillus fumigatus and Criptococcus Neoformans and occasionally with Β(1, 6)-linked branching of a single glucosyl residue.ab233743 has been shown to be effective in multiple models of fungal diseases including vaginal and systemic Candida infection, invasive Aspergillosis and Criptococcus Neoformans.

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Secondary Antibodies

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Sample Prep & Detection Kits

AB188287

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Aspergillus nidulans": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" }, "Candida albicans": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" } } }
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Product details

What is this antibody validated in?
Anti-1, 3 beta glucan antibody [2G8] (ab233743) is a mouse recombinant monoclonal antibody and is validated for use in ELISA in Aspergillus nidulans, Candida albicans samples.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
Produced in cell culture media.
Storage buffer
pH: 7.2 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

13-Beta-glucan is a polysaccharide composed of glucose molecules linked by beta-13 glycosidic bonds. This compound is mainly present in the cell walls of fungi bacteria and some plants. It has a complex and varied structure which can impact its molecular weight though specific mass can differ based on source and preparation. 13-Beta-glucan also known as beta-13-glucan is expressed significantly in fungal cell walls serving both structural and protective functions.
Biological function summary

13-beta-glucan plays an important role in the immune recognition process. It forms part of the pathogen-associated molecular patterns (PAMPs) recognized by pattern recognition receptors (PRRs) like Dectin-1 on immune cells therefore triggering innate immune responses. While not part of a larger protein complex 13-beta-glucan interacts closely with immune cells stimulating cytokine production and promoting phagocytosis. This interaction facilitates the body's defense against fungal and bacterial invasions.

Pathways

13-beta-glucan is integral to the immune response and signaling pathways. Its binding to receptors on immune cells like Dectin-1 initiates the NF-kB signaling pathway enhancing the expression of pro-inflammatory cytokines. Similarly because of its engagement in immune processes interactions also include the MAPK pathway. These pathways highlight the collaborative response involving proteins such as Toll-like receptors (TLRs) further coordinating immune activity against pathogens.

13-beta-glucan is especially relevant in the context of invasive fungal infections and sepsis. Elevated levels of this biomarker can indicate a fungal infection guiding diagnostic processes. Moreover its involvement in inflammatory response links it to sepsis where an excessive immune reaction can occur. This reaction involves both the glucan and the TLRs highlighting the interconnected nature of pathogen sensing and immune activation in these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information 1, 3 beta glucan
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Publications (11)

Recent publications for all applications. Explore the full list and refine your search

mBio 16:e0132125 PubMed40444466

2025

Lack of an atypical PDR transporter generates an immunogenic strain that drives a dysregulated and lethal immune response in murine lungs.

Applications

Unspecified application

Species

Unspecified reactive species

Christopher J Winski,Peter V Stuckey,Armando M Marrufo,Georgina Agyei,Robbi L Ross,Tamanna Urmi,Sarah Chapman,Felipe H Santiago-Tirado

CytoJournal 22:34 PubMed40260066

2025

A disintegrin-like and metalloproteinase 15 facilitates glioblastoma proliferation and metastasis through activation of the protease-activated receptor 1.

Applications

Unspecified application

Species

Unspecified reactive species

Rong Ren,Zuowei Li,Qiong Fang

PLoS pathogens 21:e1012865 PubMed40138332

2025

Systemic infection by Candida albicans requires FASN-α subunit induced cell wall remodeling to perturb immune response.

Applications

Unspecified application

Species

Unspecified reactive species

Yajing Zhao,Zhishan Zhou,Guiyue Cai,Dandan Zhang,Xiaoting Yu,Dongmei Li,Shuixiu Li,Zhanpeng Zhang,Dongli Zhang,Jiyao Luo,Yunfeng Hu,Aili Gao,Hong Zhang

Communications biology 7:1220 PubMed39349686

2024

The secretory protein COA1 enables Metarhizium robertsii to evade insect immune recognition during cuticle penetration.

Applications

Unspecified application

Species

Unspecified reactive species

Qiangqiang Zhang,Xuanlian Wei,Weiguo Fang,Xuenian Huang,Xing Zhang

Cell communication and signaling : CCS 22:237 PubMed38649988

2024

Neem leaf glycoprotein binding to Dectin-1 receptors on dendritic cell induces type-1 immunity through CARD9 mediated intracellular signal to NFκB.

Applications

Unspecified application

Species

Unspecified reactive species

Nilanjan Ganguly,Tapasi Das,Avishek Bhuniya,Ipsita Guha,Mohona Chakravarti,Sukanya Dhar,Anirban Sarkar,Saurav Bera,Jesmita Dhar,Shayani Dasgupta,Akata Saha,Tithi Ghosh,Juhina Das,Ugir Hossain Sk,Saptak Banerjee,Subrata Laskar,Anamika Bose,Rathindranath Baral

Microbial cell factories 23:28 PubMed38243245

2024

How do the carbon and nitrogen sources affect the synthesis of β-(1,3/1,6)-glucan, its structure and the susceptibility of Candida utilis yeast cells to immunolabelling with β-(1,3)-glucan monoclonal antibodies?

Applications

Unspecified application

Species

Unspecified reactive species

Anna Bzducha-Wróbel,Pavol Farkaš,Sandra Bieliková,Alžbeta Čížová,Marzena Sujkowska-Rybkowska

Nature communications 14:6718 PubMed37872182

2023

C-type lectin receptor 2d forms homodimers and heterodimers with TLR2 to negatively regulate IRF5-mediated antifungal immunity.

Applications

Unspecified application

Species

Unspecified reactive species

Fan Li,Hui Wang,Yan-Qi Li,Yebo Gu,Xin-Ming Jia

Frontiers in fungal biology 4: PubMed37538303

2023

Cell wall composition in is media dependent and alters host response, inducing protective immunity.

Applications

Unspecified application

Species

Unspecified reactive species

Rajendra Upadhya,Woei C Lam,Camaron R Hole,Joseph G Vasselli,Jennifer K Lodge

Cell 185:3789-3806.e17 PubMed36179670

2022

Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions.

Applications

Unspecified application

Species

Unspecified reactive species

Lian Narunsky-Haziza,Gregory D Sepich-Poore,Ilana Livyatan,Omer Asraf,Cameron Martino,Deborah Nejman,Nancy Gavert,Jason E Stajich,Guy Amit,Antonio González,Stephen Wandro,Gili Perry,Ruthie Ariel,Arnon Meltser,Justin P Shaffer,Qiyun Zhu,Nora Balint-Lahat,Iris Barshack,Maya Dadiani,Einav N Gal-Yam,Sandip Pravin Patel,Amir Bashan,Austin D Swafford,Yitzhak Pilpel,Rob Knight,Ravid Straussman

Frontiers in microbiology 11:534118 PubMed33123097

2020

EphA2-Dependent Internalization of Conidia in A549 Lung Cells Is Modulated by DHN-Melanin.

Applications

Unspecified application

Species

Unspecified reactive species

Esther M Keizer,Han A B Wösten,Hans de Cock
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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