Mouse Monoclonal 1, 3 beta glucan antibody. Suitable for ELISA and reacts with Aspergillus nidulans, Candida albicans samples. Cited in 4 publications. Immunogen corresponding to Chemical / Small Molecule corresponding to 1, 3 beta glucan.
pH: 7.2
Constituents: 100% PBS
| ELISA | |
|---|---|
| Aspergillus nidulans | Expected |
| Candida albicans | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Aspergillus nidulans, Candida albicans | Dilution info Use at an assay dependent concentration. | Notes - |
Mouse Monoclonal 1, 3 beta glucan antibody. Suitable for ELISA and reacts with Aspergillus nidulans, Candida albicans samples. Cited in 4 publications. Immunogen corresponding to Chemical / Small Molecule corresponding to 1, 3 beta glucan.
pH: 7.2
Constituents: 100% PBS
ab233743 reacts with 1,3 β- glucan from Candida albicans, Aspergillus fumigatus and Criptococcus Neoformans and occasionally with β(1, 6)-linked branching of a single glucosyl residue.
ab233743 has been shown to be effective in multiple models of fungal diseases including vaginal and systemic Candida infection, invasive Aspergillosis and Criptococcus Neoformans.
Produced in cell culture media.
13-Beta-glucan is a polysaccharide composed of glucose molecules linked by beta-13 glycosidic bonds. This compound is mainly present in the cell walls of fungi bacteria and some plants. It has a complex and varied structure which can impact its molecular weight though specific mass can differ based on source and preparation. 13-Beta-glucan also known as beta-13-glucan is expressed significantly in fungal cell walls serving both structural and protective functions.
13-beta-glucan plays an important role in the immune recognition process. It forms part of the pathogen-associated molecular patterns (PAMPs) recognized by pattern recognition receptors (PRRs) like Dectin-1 on immune cells therefore triggering innate immune responses. While not part of a larger protein complex 13-beta-glucan interacts closely with immune cells stimulating cytokine production and promoting phagocytosis. This interaction facilitates the body's defense against fungal and bacterial invasions.
13-beta-glucan is integral to the immune response and signaling pathways. Its binding to receptors on immune cells like Dectin-1 initiates the NF-kB signaling pathway enhancing the expression of pro-inflammatory cytokines. Similarly because of its engagement in immune processes interactions also include the MAPK pathway. These pathways highlight the collaborative response involving proteins such as Toll-like receptors (TLRs) further coordinating immune activity against pathogens.
13-beta-glucan is especially relevant in the context of invasive fungal infections and sepsis. Elevated levels of this biomarker can indicate a fungal infection guiding diagnostic processes. Moreover its involvement in inflammatory response links it to sepsis where an excessive immune reaction can occur. This reaction involves both the glucan and the TLRs highlighting the interconnected nature of pathogen sensing and immune activation in these conditions.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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