Anti-14-3-3 beta + zeta (phospho S184 + S186) antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The 14-3-3 beta and zeta proteins also known as YWHAB and YWHAZ respectively are part of the 14-3-3 protein family which typically includes proteins that are approximately 30 kDa in size. These proteins are highly expressed in the brain tissue and are found in other tissues too. The 14-3-3 proteins are known for their role in dimerization making them important in binding and stabilizing various phosphorylated client proteins. This dimerization allows them to act as scaffolding proteins facilitating the interaction and regulation of various signaling proteins.

Biological function summary

These proteins participate in a wide range of cellular processes mainly through their involvement in signal transduction pathways. They are an integral part of complex interactions within the cell often forming dimers to interact with phosphoserine-containing proteins. The 14-3-3 beta and zeta proteins play key roles in processes like apoptosis cell cycle control and cellular stress responses. Their ability to influence the activity of transcription factors and enzymes makes them important in maintaining cellular homeostasis.

Pathways

The 14-3-3 beta and zeta proteins are significant players in the MAPK and PI3K/AKT signaling pathways. These pathways are critical for regulating cell growth survival and apoptosis. They interact with proteins such as Raf-1 and Bad impacting kinase activities and apoptosis regulation. The role of 14-3-3 proteins as modulators and coordinators of these signaling cascades highlights their importance in cellular processes.

Associated diseases and disorders

These proteins have associations with neurological and cancer-related diseases. In neurological contexts dysregulation of 14-3-3 proteins links to Alzheimer’s disease where aberrant interactions may contribute to tau phosphorylation anomalies. In cancer their interaction with key regulatory proteins like p53 impacts cellular proliferation and tumor suppression. These connections highlight the potential for 14-3-3 beta and zeta as therapeutic targets in various pathological states.