Anti-14-3-3 sigma/SFN antibody [CPTC-SFN-2]
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(1 Publication)
Mouse Monoclonal 1433S antibody. Suitable for WB, Protein Array, IHC-P and reacts with Human, Recombinant full length protein - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SFN.
View Alternative Names
HME1, SFN, 14-3-3 protein sigma, Epithelial cell marker protein 1, Stratifin
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-14-3-3 sigma/SFN antibody [CPTC-SFN-2] (AB268067)
Formalin-fixed, paraffin-embedded human Skin stained for 14-3-3 Sigma/SFN using ab268067 at 2 μg/ml in immunohistochemical analysis.
- WB
Unknown
Western blot - Anti-14-3-3 sigma/SFN antibody [CPTC-SFN-2] (AB268067)
All lanes:
Western blot - Anti-14-3-3 sigma/SFN antibody [CPTC-SFN-2] (ab268067) at 2 µg/mL
All lanes:
PC-3 (Human prostate adenocarcinoma cell line) whole cell lysate
Predicted band size: 27 kDa
false
- Protein Array
Unknown
Protein Array - Anti-14-3-3 sigma/SFN antibody [CPTC-SFN-2] (AB268067)
Protein Array containing more than 19,000 full-length human proteins using ab268067. Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Reactivity data
Properties and storage information
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Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
14-3-3 sigma contributes to cell cycle arrest and apoptosis. As part of a complex it interacts with other proteins to ensure proper cell division and prevent abnormal growth. It binds to phosphorylated serine/threonine residues on its target proteins influencing their activity and function. By doing this it exerts control over cell cycle checkpoints and influences DNA damage response mechanisms.
Pathways
14-3-3 sigma interacts with several pathways that are critical for maintaining cell stability and response to stress. It participates in the PI3K/AKT pathway working closely with proteins like AKT1 to facilitate cell survival and growth suppression under stress conditions. Its involvement in this pathway ties it to the regulation of cell proliferation and survival interconnecting with broader cellular networks.
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Target data
Publications (1)
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Oncology letters 28:530 PubMed39290955
2024
Applications
Unspecified application
Species
Unspecified reactive species
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