Anti-17-beta-Estradiol antibody [EPPTX-R2]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

17-beta-Estradiol also known simply as estradiol or beta-estradiol is a steroid hormone and a member of the estrogen family. It has a molecular mass of approximately 272.39 g/mol. This hormone is synthesized mainly in the ovaries and to a lesser extent in the adrenal glands and the male testes. In cellular mechanics 17-beta-Estradiol functions by entering cells and binding to specific nuclear estrogen receptors alpha (ERα) and beta (ERβ). This binding triggers changes in the cell influencing gene expression and cellular activity.

Biological function summary

17-beta-Estradiol exerts significant roles in reproductive systems such as regulating the menstrual cycle and maintaining pregnancy. It is part of the steroid hormone pathway working closely with proteins like progesterone receptors. Besides its reproductive functions 17-beta-Estradiol impacts bone density cardiovascular health and brain function highlighting its systemic importance. It does not form part of a protein complex but interacts with multiple transcription factors to execute its functions.

Pathways

Hormone synthesis and regulation pathways prominently feature 17-beta-Estradiol. It takes part in the hypothalamic-pituitary-gonadal axis where it collaborates with luteinizing hormone (LH) and follicle-stimulating hormone (FSH) to regulate reproductive functions. Additionally 17-beta-Estradiol contributes to the bone remodeling pathway by affecting osteoclast and osteoblast activity together with proteins like RANKL and OPG.

Associated diseases and disorders

17-beta-Estradiol has been strongly linked to conditions such as breast cancer and osteoporosis. It influences breast cancer progression by interacting with various receptor proteins including HER2 and progesterone receptor leading to proliferation in certain cancerous cells. In osteoporosis insufficient levels of 17-beta-Estradiol lead to increased bone resorption and decreased bone formation linking it to proteins like collagen and osteocalcin involved in bone structure and strength maintenance.