Anti-2-methyladenosine (m2A) antibody [EPR -19851-59] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

2-methyladenosine (m2A) is a modified nucleoside that plays a significant role in RNA structures impacting RNA stability and function. It is an adenosine derivative where a methyl group is added to the nitrogen at position 2 of the adenine ring altering its chemical properties. This modification has a relatively small molecular mass of approximately 281.3 Da. m2A is found primarily in tRNA and rRNA molecules within the cell contributing to their proper folding and stability. It is ubiquitously expressed across various tissues reflecting its broad functional significance.

Biological function summary

The modification of RNA by 2-methyladenosine contributes significantly to RNA processing and function. It plays a role in the structural integrity and proper folding of tRNA and rRNA by maintaining the stability of the RNA molecules they modify. m2A acts within ribonucleoprotein complexes where it influences the recognition and interaction between RNA and protein components. This modification ensures the accuracy of translation by maintaining the correct conformation of the RNA molecules involved in protein synthesis.

Pathways

2-methyladenosine engages in essential biological processes such as translation and RNA processing. It is involved in the ribosome biogenesis pathway which is important for protein synthesis in cells. Within this pathway m2A interacts with other RNA modifications and proteins like the ribosomal proteins and various RNA-binding proteins that guide RNA through the maturation process. The presence of m2A aids the efficient assembly of ribosomal units necessary for the synthesis of proteins.

Associated diseases and disorders

Altered levels of 2-methyladenosine have been implicated in disorders related to dysfunction in protein synthesis. Aberrant m2A modification has been linked to certain cancers wherein improper RNA processing might contribute to uncontrolled cellular proliferation. Additionally it relates to neurodegenerative diseases where misfolded proteins result from translation dysregulation. In this context m2A modifications can affect the function of proteins such as ribosome-associated proteins and those involved in RNA methylation influencing disease outcomes through changes in RNA stability and processing.