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AB237539

Anti-24p3R antibody

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(1 Publication)

Rabbit Polyclonal 24p3R antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC22A17 aa 1-100.

View Alternative Names

BOCT, BOIT, SLC22A17, Solute carrier family 22 member 17, 24p3 receptor, Brain-type organic cation transporter, Lipocalin-2 receptor, Neutrophil gelatinase-associated lipocalin receptor, 24p3R, NgalR

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-24p3R antibody (AB237539)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-24p3R antibody (AB237539)

A549 (Human lung carcinoma cell line) cells stained for 24p3R (green) using ab237539 at 1/100 dilution in ICC/IF, followed by an Alexa-Fluor®488 conjugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-24p3R antibody (AB237539)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-24p3R antibody (AB237539)

Paraffin-embedded human cervical cancer tissue stained for 24p3R using ab237539 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SLC22A17 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q8WUG5

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Complementary Products

Primary Antibodies

AB125075

Anti-Lipocalin-2 / NGAL antibody [EPR5084]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-Lipocalin-2 / NGAL antibody [EPR5084] (AB125075)

  • 5
  • 1
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Proteins & Peptides

AB153343

Recombinant Human 24p3R protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human 24p3R protein (GST tag N-Terminus) (AB153343)

  • 0
  • 0
Primary Antibodies

AB70362

Anti-ADIPOR1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ADIPOR1 antibody (AB70362)

  • 3
  • 9
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/500", "ICCIF-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity greater than 95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The 24p3R also known as SLC22A17 or neutrophil gelatinase-associated lipocalin receptor is a receptor protein that facilitates cellular uptake of its ligand the neutrophil gelatinase-associated lipocalin (NGAL) known scientifically as lipocalin-2. This receptor with a molecular mass of approximately 55 kDa participates in iron regulation by binding and internalizing iron-laden NGAL. Expression of 24p3R occurs across various tissues with significant presence in kidney liver and spleen reflecting its systemic role in iron homeostasis.
Biological function summary

The NGAL and 24p3R interaction plays a critical role in iron metabolism and immune response. The receptor delivers NGAL-bound iron to cells impacting the cell's iron availability an essential process for many cellular functions and maintaining systemic iron balance. This interaction does not occur in isolation; 24p3R operates within a larger complex network involving other iron-regulating proteins like transferrin which collectively orchestrate iron absorption distribution and storage in the body.

Pathways

24p3R functions within the iron metabolism pathway essential for iron uptake and regulation. Its interaction with NGAL is related to the transferrin receptor pathway which regulates iron uptake through transferrin-bound iron. These interactions highlight the role of 24p3R beyond the basic cellular uptake of NGAL influencing systemic iron distribution and maintaining cellular iron homeostasis. Proteins like transferrin family members modulate this pathway and are integral to the function of 24p3R in cellular iron control.

24p3R involvement is directly linked to conditions characterized by iron imbalance such as iron deficiency anemia and chronic kidney disease. Aberrant expression or function of 24p3R can contribute to these diseases through disturbed iron metabolism. In these contexts NGAL levels often elevated act as markers of disrupted iron homeostasis and inflammation further associating 24p3R with the pathological processes. By connecting with NGAL 24p3R plays a role in these diseases highlighting its importance in maintaining iron equilibrium in health and disease.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).
See full target information SLC22A17
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 9:801687 PubMed35096829

2022

Identification and Validation of Key Genes of Differential Correlations in Gastric Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Tingna Chen,Qiuming He,Zhenxian Xiang,Rongzhang Dou,Bin Xiong
View all publications
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Product promise

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