Rabbit Polyclonal 4E-BP2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Eukaryotic translation initiation factor 4E-binding protein 2 aa 50 to C-terminus conjugated to Keyhole Limpet Haemocyanin.
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Eukaryotic translation initiation factor 4E-binding protein 2, 4E-BP2, eIF4E-binding protein 2, EIF4EBP2
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-4E-BP2 antibody (AB111309)
Immunohistochemistry Image of Human Pancreas Formalin Fixed and Paraffin Embedded (FFPE) and stained with ab111309 at 10μg/ml. After incubation with the primary antibody, slides were incubated with biotinylated Goat anti Rabbit secondary antibody, followed by alkaline phosphatase streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity.
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Biological function summary
The 4E-BP2 protein inhibits the initiation of protein synthesis regulating gene expression at a translational level. 4E-BP2 does not form part of a stable complex but transiently interacts with eIF4E in response to different cellular signals. When 4E-BP2 is phosphorylated by mammalian target of rapamycin (mTOR) it undergoes a conformational change that weakens its binding to eIF4E allowing protein synthesis to proceed. This regulation exhibits tissue specificity and involves responses to growth factors nutrients and cellular stress.
Pathways
The involvement of 4E-BP2 is important in the mTOR signaling pathway a central pathway regulating cell growth and metabolism in response to environmental cues. The mTOR pathway includes other proteins like eIF4E which 4E-BP2 interacts with directly and mTOR itself which phosphorylates 4E-BP2. Additionally 4E-BP2 also participates in the insulin signaling pathway influencing how cells respond to insulin and other growth factors by regulating protein translation.
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Publications (1)
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Oncotarget 7:1421-38 PubMed26623558
2015
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