AB13896

Anti-5HT1B Receptor antibody

Name: Anti-5HT1B Receptor antibody (ab13896) | Abcam
Brand: Abcam Limited
SKU: AB13896
Price: 535 USD
Availability: InStock
Rating: 2 (4 reviews)

(4 Reviews)

(23 Publications)

Rabbit Polyclonal 5HT1B Receptor antibody. Suitable for WB and reacts with Human samples. Cited in 23 publications. Immunogen corresponding to Synthetic Peptide within Rat Htr1b.

View Alternative Names

HTR1DB, HTR1B, 5-hydroxytryptamine receptor 1B, 5-HT-1B, 5-HT1B, S12, Serotonin 1D beta receptor, Serotonin receptor 1B, 5-HT-1D-beta

1 Images

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Western blot - Anti-5HT1B Receptor antibody (AB13896)

Western blot analysis of 5HT1B Receptor in human brain lysate with ab13896. A protein band of approximate molecular weight of 40-41kDa was detected. Western blot analysis of 5HT1B Receptor in human brain lysate with ab13896. A protein band of approximate molecular weight of 40-41kDa was detected.

All lanes:

Western blot - Anti-5HT1B Receptor antibody (ab13896)

Predicted band size: 44 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Rat Htr1b. The exact immunogen used to generate this antibody is proprietary information.

P28564

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "4 µg/mL", "IHCP-species-notes": "", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "" }, "Mouse": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

This antibody is affinity purified.

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The 5-HT1B receptor also known as the serotonin 1B receptor or HTR1B is a G protein-coupled receptor with a molecular mass of approximately 41 kDa. It binds serotonin an important neurotransmitter in the central nervous system. The 5-HT1B receptor is expressed in various brain regions including the striatum basal ganglia and frontal cortex. This receptor modulates neurotransmission by inhibiting the release of serotonin and other neurotransmitters like dopamine. Interruptions in its function can significantly affect synaptic plasticity and neuronal activity.

Biological function summary

The 5-HT1B receptor plays a role in regulating aggressive behavior mood and appetite. It is part of a larger serotonin receptor family and works in conjunction with other receptor subtypes to maintain effective serotonergic signaling. By influencing dopamine and GABAergic systems the 5-HT1B receptor contributes to neural inhibition and the modulation of reward pathways. Alterations in its activity could influence emotional regulation and various behavioral responses.

Pathways

The 5-HT1B receptor participates significantly in the serotonin signaling pathway and MAPK signaling pathway. Interacting with proteins such as G protein-coupled receptor kinases and beta-arrestins it influences downstream effects that include modulation of cAMP levels and changes in phosphatidylinositol turnover. Disturbances in these pathways can affect mood and behavior implicating the 5-HT1B receptor in various neurological pathways.

Irregular function of the 5-HT1B receptor links to conditions such as depression and migraine. This receptor through its role in mood regulation implicates it in mood disorders if dysregulated. It also connects to genetic factors influencing migraine possibly through interactions with proteins like calcitonin gene-related peptide (CGRP). Despite the complexity of these conditions the 5-HT1B receptor is a potential target for therapeutic interventions suggesting its importance in disease mechanisms.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed : 10452531, PubMed : 1315531, PubMed : 1328844, PubMed : 1348246, PubMed : 1351684, PubMed : 1559993, PubMed : 1565658, PubMed : 1610347, PubMed : 23519210, PubMed : 23519215, PubMed : 29925951, PubMed : 8218242). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD) (PubMed : 23519210, PubMed : 23519215, PubMed : 29925951). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed : 10452531, PubMed : 1315531, PubMed : 1328844, PubMed : 1348246, PubMed : 1351684, PubMed : 1559993, PubMed : 1565658, PubMed : 1610347, PubMed : 23519210, PubMed : 23519215, PubMed : 29925951, PubMed : 8218242). HTR1B is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (PubMed : 29925951, PubMed : 35610220). Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed : 29925951). Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior (PubMed : 18476671, PubMed : 20945968). Besides, plays a role in vasoconstriction of cerebral arteries (PubMed : 15853772).

See full target information HTR1B

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Publications (23)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:23377 PubMed40604023

2025

Modulation of vestibular function and receptor expression by experimental hypergravity in a rat model.

Applications

Unspecified application

Species

Unspecified reactive species

Jin Sil Choi,Ji Eun Hong,Yoon Kun Jung,Kyu-Sung Kim,Hyun Ji Kim

Neurobiology of disease 183:106179 PubMed37276987

2023

Reduction of aggressive behaviour following hypothalamic deep brain stimulation: Involvement of 5-HT and testosterone.

Applications

Unspecified application

Species

Unspecified reactive species

Flavia Venetucci Gouveia,Mustansir Diwan,Raquel C R Martinez,Peter Giacobbe,Nir Lipsman,Clement Hamani

Nutrition research and practice 17:408-420 PubMed37266125

2023

Dopamine and serotonin alterations by extracts under cortical primary neuronal cell cultures.

Applications

Unspecified application

Species

Unspecified reactive species

Jae-Won Jung,Ye-Jin Kim,Jae Sue Choi,Yukiori Goto,Young-A Lee

Neuron 111:711-726.e11 PubMed36584680

2022

Brainstem serotonin neurons selectively gate retinal information flow to thalamus.

Applications

Unspecified application

Species

Unspecified reactive species

Jasmine D S Reggiani,Qiufen Jiang,Melanie Barbini,Andrew Lutas,Liang Liang,Jesseba Fernando,Fei Deng,Jinxia Wan,Yulong Li,Chinfei Chen,Mark L Andermann

The journal of headache and pain 23:26 PubMed35177004

2022

Lasmiditan and 5-Hydroxytryptamine in the rat trigeminal system; expression, release and interactions with 5-HT receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Jacob C A Edvinsson,Aida Maddahi,Isabella M Christiansen,Philip V Reducha,Karin Warfvinge,Majid Sheykhzade,Lars Edvinsson,Kristian A Haanes

International journal of molecular sciences 22: PubMed34638540

2021

Improvement Effects of Myelophil on Symptoms of Chronic Fatigue Syndrome in a Reserpine-Induced Mouse Model.

Applications

Unspecified application

Species

Unspecified reactive species

Ji-Hye Song,Seul-Ki Won,Geun-Hyang Eom,Da-Som Lee,Byung-Jin Park,Jin-Seok Lee,Chang-Gue Son,Ji-Yeun Park

Journal of ethnopharmacology 237:39-46 PubMed30880256

2019

Alkaloids from the rhizomes of Ligusticum striatum exert antimigraine effects through regulating 5-HT receptor and c-Jun.

Applications

Unspecified application

Species

Unspecified reactive species

Zhong-Hui Pu,Cheng Peng,Xiao-Fang Xie,Min Luo,Huan Zhu,Rui Feng,Liang Xiong

Neuroscience 393:319-332 PubMed30336190

2018

Expression of Pituitary Adenylate Cyclase-activating Peptide, Calcitonin Gene-related Peptide and Headache Targets in the Trigeminal Ganglia of Rats and Humans.

Applications

Unspecified application

Species

Unspecified reactive species

Simona Denise Frederiksen,Karin Warfvinge,Lena Ohlsson,Lars Edvinsson

Brain research bulletin 139:256-262 PubMed29524471

2018

Electroacupuncture restores hippocampal synaptic plasticity via modulation of 5-HT receptors in a rat model of depression.

Applications

Species

Unspecified reactive species

Xuke Han,Huangan Wu,Ping Yin,Zeqin Chen,Xiaohua Cao,Yanhong Duan,Jian Xu,Lixing Lao,Shifen Xu

Nature medicine 23:733-741 PubMed28459438

2017

Pericytes impair capillary blood flow and motor function after chronic spinal cord injury.

Applications

IHC

Species

Rat

Yaqing Li,Ana M Lucas-Osma,Sophie Black,Mischa V Bandet,Marilee J Stephens,Romana Vavrek,Leo Sanelli,Keith K Fenrich,Antonio F Di Narzo,Stella Dracheva,Ian R Winship,Karim Fouad,David J Bennett

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-5HT1B Receptor antibody

Western blot - Anti-5HT1B Receptor antibody (AB13896)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (23)

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