AB85937

Anti-5HT1B Receptor antibody

(3 Reviews)

(1 Publication)

Rabbit Polyclonal 5HT1B Receptor antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

HTR1DB, HTR1B, 5-hydroxytryptamine receptor 1B, 5-HT-1B, 5-HT1B, S12, Serotonin 1D beta receptor, Serotonin receptor 1B, 5-HT-1D-beta

1 Images

Unknown

Western blot - Anti-5HT1B Receptor antibody (AB85937)

All lanes:

5HT1B Receptor antibody at 1 µg/mL

All lanes:

Human brain tissue lysate - total protein (<a href='/en-us/products/unavailable/human-brain-tissue-lysate-total-protein-ab29466'>ab29466</a>) at 10 µg

Secondary

All lanes:

Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Predicted band size: 44 kDa

Observed band size: 43 kDa

true

Exposure time: 20min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

This antibody has been sucessfully used on rat tissue in IHC. Since the immunogen only shares 84% homology, customers may get variable results. Please see the abreview for more details.

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Reactivity data

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The 5-HT1B receptor also known as the serotonin 1B receptor or HTR1B is a G protein-coupled receptor with a molecular mass of approximately 41 kDa. It binds serotonin an important neurotransmitter in the central nervous system. The 5-HT1B receptor is expressed in various brain regions including the striatum basal ganglia and frontal cortex. This receptor modulates neurotransmission by inhibiting the release of serotonin and other neurotransmitters like dopamine. Interruptions in its function can significantly affect synaptic plasticity and neuronal activity.

Biological function summary

The 5-HT1B receptor plays a role in regulating aggressive behavior mood and appetite. It is part of a larger serotonin receptor family and works in conjunction with other receptor subtypes to maintain effective serotonergic signaling. By influencing dopamine and GABAergic systems the 5-HT1B receptor contributes to neural inhibition and the modulation of reward pathways. Alterations in its activity could influence emotional regulation and various behavioral responses.

Pathways

The 5-HT1B receptor participates significantly in the serotonin signaling pathway and MAPK signaling pathway. Interacting with proteins such as G protein-coupled receptor kinases and beta-arrestins it influences downstream effects that include modulation of cAMP levels and changes in phosphatidylinositol turnover. Disturbances in these pathways can affect mood and behavior implicating the 5-HT1B receptor in various neurological pathways.

Irregular function of the 5-HT1B receptor links to conditions such as depression and migraine. This receptor through its role in mood regulation implicates it in mood disorders if dysregulated. It also connects to genetic factors influencing migraine possibly through interactions with proteins like calcitonin gene-related peptide (CGRP). Despite the complexity of these conditions the 5-HT1B receptor is a potential target for therapeutic interventions suggesting its importance in disease mechanisms.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed : 10452531, PubMed : 1315531, PubMed : 1328844, PubMed : 1348246, PubMed : 1351684, PubMed : 1559993, PubMed : 1565658, PubMed : 1610347, PubMed : 23519210, PubMed : 23519215, PubMed : 29925951, PubMed : 8218242). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD) (PubMed : 23519210, PubMed : 23519215, PubMed : 29925951). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed : 10452531, PubMed : 1315531, PubMed : 1328844, PubMed : 1348246, PubMed : 1351684, PubMed : 1559993, PubMed : 1565658, PubMed : 1610347, PubMed : 23519210, PubMed : 23519215, PubMed : 29925951, PubMed : 8218242). HTR1B is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (PubMed : 29925951, PubMed : 35610220). Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed : 29925951). Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior (PubMed : 18476671, PubMed : 20945968). Besides, plays a role in vasoconstriction of cerebral arteries (PubMed : 15853772).

See full target information HTR1B

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Genome research 24:1396-410 PubMed24904046

2014

Digital expression profiling of the compartmentalized translatome of Purkinje neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Anton Kratz,Pascal Beguin,Megumi Kaneko,Takahiko Chimura,Ana Maria Suzuki,Atsuko Matsunaga,Sachi Kato,Nicolas Bertin,Timo Lassmann,Réjan Vigot,Piero Carninci,Charles Plessy,Thomas Launey

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-5HT1B Receptor antibody

Western blot - Anti-5HT1B Receptor antibody (AB85937)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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