Rabbit Polyclonal 5HT1F Receptor antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human HTR1F.
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Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.099% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human HTR1F. The exact immunogen used to generate this antibody is proprietary information. Database link P30939
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Chimpanzee | Predicted |
| Cow | Predicted |
| Gorilla | Predicted |
| Guinea pig | Predicted |
| Orangutan | Predicted |
| Rabbit | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 5.00000-8.00000 µg/mL | Notes Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rabbit, Guinea pig, Cow, Chimpanzee, Gorilla, Orangutan | Dilution info - | Notes - |
Associated Products
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Target data
Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:21422162, PubMed:34239069, PubMed:8380639, PubMed:8384716). Also functions as a receptor for various alkaloids and psychoactive substances (PubMed:21422162, PubMed:8380639, PubMed:8384716). Receptor for lasmiditan, a drug for the treatment of acute migraine (PubMed:34239069). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:34239069). HTR1F is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (PubMed:34239069, PubMed:35610220).
Alternative names
HTR1EL, HTR1F, 5-hydroxytryptamine receptor 1F, 5-HT-1F, 5-HT1F, Serotonin receptor 1F
Recommended products
Rabbit Polyclonal 5HT1F Receptor antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human HTR1F.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.099% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human HTR1F. The exact immunogen used to generate this antibody is proprietary information. Database link P30939
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The 5HT1F receptor also known as the serotonin 1F receptor is a G protein-coupled receptor involved in the neurotransmission of serotonin. It has an approximate molecular mass of 40 kDa. Expression of 5HT1F occurs mainly in the brain specifically in areas such as the cortex and hippocampus as well as in peripheral tissues like the trigeminal ganglia. This receptor plays a role in inhibiting adenylate cyclase activity impacting various cellular responses.
- Biological function summary
The 5HT1F receptor modulates neurotransmitter release and neuronal excitability. It achieves this by affecting serotonin signaling pathways impacting mood cognition and perception. One could find 5HT1F as part of the complex neural network that regulates these factors. Although it operates as an individual receptor it interacts with other serotonin receptor subtypes contributing to a more comprehensive neurotransmission environment.
- Pathways
The 5HT1F receptor takes part in the serotonin signaling pathway and the nociception pathway. These pathways play significant roles in the modulation of pain and mood. In the serotonin signaling pathway the 5HT1F interacts with proteins involved in serotonin metabolism such as serotonin transporters and other serotonin receptor subtypes. Its relationship with the nociception pathway assists in the regulation of pain perception through modulation of neuronal excitability.
- Associated diseases and disorders
The 5HT1F receptor relates to migraine and depression. It serves as a potential therapeutic target for migraine management because of its role in the trigeminal system and pain signaling. During migraine attacks selective agonists targeting 5HT1F can reduce symptoms without causing vasoconstriction unlike 5HT1B receptors. In depression its involvement in serotonin transmission offers a connection with other serotonin receptors suggesting potential implications for therapeutic strategies addressing mood disorders.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-5HT1F Receptor antibody (ab230794)
Formalin-fixed, paraffin-embedded human kidney (renal tubules) tissue stained for 5HT1F Receptor with ab230794 at 8 μg/ml in immunohistochemical analysis.
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