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AB230794

Anti-5HT1F Receptor antibody

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(1 Publication)

Rabbit Polyclonal 5HT1F Receptor antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human HTR1F.

View Alternative Names

HTR1EL, HTR1F, 5-hydroxytryptamine receptor 1F, 5-HT-1F, 5-HT1F, Serotonin receptor 1F

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-5HT1F Receptor antibody (AB230794)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-5HT1F Receptor antibody (AB230794)

Formalin-fixed, paraffin-embedded human kidney (renal tubules) tissue stained for 5HT1F Receptor with ab230794 at 8 μg/ml in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human HTR1F. The exact immunogen used to generate this antibody is proprietary information.

P30939

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-8 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Guinea pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.099% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The 5HT1F receptor also known as the serotonin 1F receptor is a G protein-coupled receptor involved in the neurotransmission of serotonin. It has an approximate molecular mass of 40 kDa. Expression of 5HT1F occurs mainly in the brain specifically in areas such as the cortex and hippocampus as well as in peripheral tissues like the trigeminal ganglia. This receptor plays a role in inhibiting adenylate cyclase activity impacting various cellular responses.
Biological function summary

The 5HT1F receptor modulates neurotransmitter release and neuronal excitability. It achieves this by affecting serotonin signaling pathways impacting mood cognition and perception. One could find 5HT1F as part of the complex neural network that regulates these factors. Although it operates as an individual receptor it interacts with other serotonin receptor subtypes contributing to a more comprehensive neurotransmission environment.

Pathways

The 5HT1F receptor takes part in the serotonin signaling pathway and the nociception pathway. These pathways play significant roles in the modulation of pain and mood. In the serotonin signaling pathway the 5HT1F interacts with proteins involved in serotonin metabolism such as serotonin transporters and other serotonin receptor subtypes. Its relationship with the nociception pathway assists in the regulation of pain perception through modulation of neuronal excitability.

The 5HT1F receptor relates to migraine and depression. It serves as a potential therapeutic target for migraine management because of its role in the trigeminal system and pain signaling. During migraine attacks selective agonists targeting 5HT1F can reduce symptoms without causing vasoconstriction unlike 5HT1B receptors. In depression its involvement in serotonin transmission offers a connection with other serotonin receptors suggesting potential implications for therapeutic strategies addressing mood disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed : 21422162, PubMed : 34239069, PubMed : 8380639, PubMed : 8384716). Also functions as a receptor for various alkaloids and psychoactive substances (PubMed : 21422162, PubMed : 8380639, PubMed : 8384716). Receptor for lasmiditan, a drug for the treatment of acute migraine (PubMed : 34239069). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed : 34239069). HTR1F is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (PubMed : 34239069, PubMed : 35610220).
See full target information HTR1F
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 23: PubMed36361598

2022

Antagonization of OX Receptor Potentiates CB Receptor Function in Microglia from APP Mice Model.

Applications

Unspecified application

Species

Unspecified reactive species

Iu Raïch,Joan Biel Rebassa,Jaume Lillo,Arnau Cordomi,Rafael Rivas-Santisteban,Alejandro Lillo,Irene Reyes-Resina,Rafael Franco,Gemma Navarro
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Product promise

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