Rabbit Polyclonal 5HT2A Receptor antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human HTR2A.
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Publications
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- Biochemical Society transactions 49:1997-20062021How neural stem cells contribute to neocortex development.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLei Xing,Michaela Wilsch-Bräuninger,Wieland B HuttnerPubMed 34397081
- Neuron 108:1113-1129.e62020Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLei Xing,Nereo Kalebic,Takashi Namba,Samir Vaid,Pauline Wimberger,Wieland B HuttnerPubMed 33080227
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human HTR2A. The exact immunogen used to generate this antibody is proprietary information. Database link P28223
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Chimpanzee | Predicted |
| Gorilla | Predicted |
| Monkey | Predicted |
| Orangutan | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 10 µg/mL | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Chimpanzee, Monkey, Gorilla, Orangutan | Dilution info - | Notes - |
Associated Products
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Target data
Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895, PubMed:21645528, PubMed:22300836, PubMed:35084960, PubMed:38552625). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538, PubMed:35084960). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:28129538, PubMed:35084960). HTR2A is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (PubMed:18703043, PubMed:28129538, PubMed:35084960). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538, PubMed:35084960). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity). (Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV.
Alternative names
HTR2, HTR2A, 5-hydroxytryptamine receptor 2A, 5-HT-2, 5-HT-2A, Serotonin receptor 2A
Recommended products
Rabbit Polyclonal 5HT2A Receptor antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human HTR2A.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human HTR2A. The exact immunogen used to generate this antibody is proprietary information. Database link P28223
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The 5HT2A receptor also known as 5-hydroxytryptamine receptor 2A is a G-protein coupled receptor with a molecular mass of approximately 52 kDa. It is one of the key receptors for serotonin (5-HT) and is chiefly expressed in the central nervous system including regions like the cortex and the basal ganglia. This receptor binds serotonin and initiates a cascade of intracellular events which can alter neuronal activity and influence various neuropsychological functions.
- Biological function summary
The 5HT2A receptor modulates cognitive functions such as learning and memory and it also plays a role in mood regulation. This receptor is involved in a complex of signaling pathways and interacts with other receptors such as the 5HT1A receptor and proteins like phospholipase C in downstream signaling. Through these interactions the receptor contributes to maintaining a balance in neurotransmitter systems.
- Pathways
This receptor is actively involved in the serotonergic signaling pathway. It participates by interacting with the phosphatidylinositol signaling system affecting intracellular calcium levels. The 5HT2A receptor works alongside other proteins such as the dopamine D2 receptor forming a link between serotonin and dopamine pathways which are integral to mood and behavior regulation.
- Associated diseases and disorders
The 5HT2A receptor is closely linked to schizophrenia and depression. Alterations in the receptor's function or expression levels have been associated with the pathophysiology of these disorders. The receptor's interactions with other proteins including the 5HT1A receptor have been implicated in the therapeutic mechanisms of antipsychotic and antidepressant medications highlighting its significance in mental health treatment strategies.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-5HT2A Receptor antibody - C-terminal (ab140524)
Immunohistochemical analysis of formalin fixed, paraffin embedded Human placenta tissue labelling 5HT2A Receptor with ab140524 at 10 µg/ml.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-5HT2A Receptor antibody - C-terminal (ab140524)
Immunohistochemical analysis of formalin fixed, paraffin embedded Human adrenal tissue labelling 5HT2A Receptor with ab140524 at 10 µg/ml.
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