JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB214211

Anti-5HT3B receptor antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Polyclonal 5HT3B receptor antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human 5-hydroxytryptamine receptor 3B aa 100-200 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

5-hydroxytryptamine receptor 3B, 5-HT3-B, 5-HT3B, Serotonin receptor 3B, HTR3B

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-5HT3B receptor antibody (AB214211)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-5HT3B receptor antibody (AB214211)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney tissue labeling 5HT3B receptor with ab214211 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human 5-hydroxytryptamine receptor 3B aa 100-200 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

O95264

style
left-column

Complementary Products

Primary Antibodies

AB13897

Anti-5HT3A receptor/5ht3 antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-5HT3A receptor/5ht3 antibody (AB13897)

  • 4
  • 8
Biochemicals

AB120511

1-Phenylbiguanide, 5-HT3 receptor agonist

Chemical Structure - 1-Phenylbiguanide, 5-HT3 receptor agonist (AB120511)

  • 0
  • 0
Primary Antibodies

AB21227

Anti-PTGER3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTGER3 antibody (AB21227)

  • 0
  • 0
Assay Kits

AB241000

Phenylalanine Assay Kit (Colorimetric)

Functional Studies - Phenylalanine Assay Kit (Colorimetric) (AB241000)

  • 5
  • 1
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The 5-HT3B receptor also known as the serotonin 3B receptor is an ionotropic receptor that plays a role in ligand-gated ion channel activity. It forms part of the 5-HT3 receptor complex which allows the flow of cations like sodium and calcium through the cell membrane when activated. This protein is approximately 54 kDa in mass. Expression of the 5-HT3B receptor is found in various tissues but it is most notable in the central and peripheral nervous systems.
Biological function summary

These receptors change cellular excitability and are integral in neurotransmission and signal transduction. As part of a functional 5-HT3 receptor complex the 5-HT3B subunit alters the ion selectivity and conductance properties of the channel. This influence impacts processes like emesis anxiety and gut motility. The receptor's activity provides a means for serotonin to exert its effects on neurons and other cell types.

Pathways

Serotonin signaling heavily involves 5-HT3B receptor especially within the central nervous system. This receptor contributes to pathways like the emetic response pathway and the regulation of mood both linked to the broad serotonergic signaling network. It interacts with other proteins such as the 5-HT3A subunit that forms the complete receptor structure affecting how serotonin modulates physiological responses.

Dysfunction in the 5-HT3B receptor links to conditions like irritable bowel syndrome (IBS) and anxiety disorders. Changes in receptor function can influence neurotransmitter release and neuronal excitability triggering or worsening symptoms of these disorders. The receptor's interaction with serotonin and its modulation makes it a target for therapeutic agents aimed at alleviating symptoms in these diseases.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.
See full target information 5-hydroxytryptamine receptor 3B
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 73:1859-1873 PubMed39235608

2024

Stored RBC transfusions leads to the systemic inflammatory response syndrome in anemic murine neonates.

Applications

Unspecified application

Species

Unspecified reactive species

Balamurugan Ramatchandirin,Marie Amalie Balamurugan,Suneetha Desiraju,Yerin Chung,Boguslaw S Wojczyk,Krishnan MohanKumar

FASEB journal : official publication of the Federa 33:10731-10741 PubMed31251077

2019

Prolongation of bronchopulmonary C-fiber-mediated apnea by prenatal nicotinic exposure in rat pups: role of 5-HT receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Zhao,Xiuping Gao,Jianguo Zhuang,Morgan Wallen,Shuguang Leng,Fadi Xu
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com