Rabbit Polyclonal 67kDa Laminin Receptor antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RPSA aa 1 to C-terminus.
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- iScience 26:1079712023Essential role of the amino-terminal region of Drosha for the Microprocessor function.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAmit Prabhakar,Song Hu,Jin Tang,Prajakta Ghatpande,Giorgio Lagna,Xuan Jiang,Akiko HataPubMed 37810246
- Scientific reports 11:91032021(-)-Epigallocatechin-3-gallate induces apoptosis and differentiation in leukaemia by targeting reactive oxygen species and PIN1.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFernanda Isabel Della Via,Rodrigo Naoto Shiraishi,Irene Santos,Karla Priscila Ferro,Myriam Janeth Salazar-Terreros,Gilberto Carlos Franchi Junior,Eduardo Magalhães Rego,Sara Teresinha Olalla Saad,Cristiane Okuda TorelloPubMed 33907248
- Science signaling 14:2021Control of ribosomal protein synthesis by the Microprocessor complex.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXuan Jiang,Amit Prabhakar,Stephanie M Van der Voorn,Prajakta Ghatpande,Barbara Celona,Srivats Venkataramanan,Lorenzo Calviello,Chuwen Lin,Wanpeng Wang,Brian L Black,Stephen N Floor,Giorgio Lagna,Akiko HataPubMed 33622983
- International journal of molecular sciences 21:2020AAV-Mediated Gene Delivery to 3D Retinal Organoids Derived from Human Induced Pluripotent Stem Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarcela Garita-Hernandez et. al.PubMed 32028585
- Scientific reports 9:130902019Prion protein modulates endothelial to mesenchyme-like transition in trabecular meshwork cells: Implications for primary open angle glaucoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAjay Ashok et. al.PubMed 31511544
- Cell 173:90-103.e192018Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRajiv K Khajuria et. al.PubMed 29551269
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 78% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human RPSA aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P08865
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Reactivity data
Select an application| IHC-P | WB | ICC/IF | |
|---|---|---|---|
| Human | Tested | Tested | Tested |
| Mouse | Expected | Tested | Expected |
| Rat | Predicted | Predicted | Predicted |
| Cow | Predicted | Predicted | Predicted |
| Monkey | Predicted | Predicted | Predicted |
| Pig | Predicted | Predicted | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100 - 1/1000 | Notes or Tris-EDTA buffer (pH8.0) Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat, Cow, Pig, Monkey | Dilution info - | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/500 - 1/3000 | Notes - |
Species Human | Dilution info 1/500 - 1/3000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat, Cow, Pig, Monkey | Dilution info - | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100 - 1/1000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat, Cow, Pig, Monkey | Dilution info - | Notes - |
Associated Products
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Target data
Function
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9. (Microbial infection) Acts as a receptor for the Dengue virus. (Microbial infection) Acts as a receptor for the Sindbis virus. (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus. (Microbial infection) Acts as a receptor for the pathogenic prion protein. (Microbial infection) Acts as a receptor for bacteria.
Alternative names
LAMBR, LAMR1, RPSA, Small ribosomal subunit protein uS2, 37 kDa laminin receptor precursor, 37/67 kDa laminin receptor, 40S ribosomal protein SA, 67 kDa laminin receptor, Colon carcinoma laminin-binding protein, Laminin receptor 1, Laminin-binding protein precursor p40, Multidrug resistance-associated protein MGr1-Ag, NEM/1CHD4, 37LRP, LRP/LR, 67LR, LamR, LBP/p40
Recommended products
Rabbit Polyclonal 67kDa Laminin Receptor antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RPSA aa 1 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 78% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human RPSA aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P08865
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The 67kDa Laminin Receptor also known as the laminin binding protein or protein laminin functions as a receptor for laminin an important component of the extracellular matrix. This receptor is expressed in many tissue types serving an important mechanical role by mediating the adhesion and migration of cells. The receptor anchors cells to laminin molecules thereby influencing cell differentiation and proliferation. The molecular weight of the laminin receptor is approximately 67 kilodaltons which signifies it as a critical player in various cellular processes.
- Biological function summary
This receptor engages in cellular interactions that are essential for maintaining the integrity and architecture of tissues. It often associates with other proteins to form complexes which further strengthen its functional capabilities. By anchoring laminin to the cell surface it regulates cell signaling pathways that influence cell motility invasion and survival. These interactions suggest that the 67kDa Laminin Receptor's function goes beyond simple adhesion impacting cellular responsiveness to external matrix cues.
- Pathways
The receptor influences the MAPK and PI3K/Akt signaling pathways which are significant in cell survival and proliferation. Through such pathways it interacts with numerous proteins including integrins and fibronectin receptors facilitating orchestrated cell signaling. This connectivity highlights the receptor's role in cellular communication networks contributing to dynamic processes like wound healing and angiogenesis.
- Associated diseases and disorders
Aberrant expression of the 67kDa Laminin Receptor relates to conditions such as cancer and Alzheimer's disease. In cancer its overexpression links to increased tumor invasiveness likely due to enhanced cell motility mediated through integrin interactions. In Alzheimer's disease its relationship with amyloid precursor protein influences plaque formation exacerbating disease progression. Understanding these connections highlights potential therapeutic targets for disease intervention.
Product promise
Tested
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Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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4 product images
Western blot - Anti-67kDa Laminin Receptor antibody (ab137388)
12% SDS PAGE
All lanes: Western blot - Anti-67kDa Laminin Receptor antibody (ab137388) at 1/1000 dilution
All lanes: HepG2 whole cell lysate at 30 µg
Predicted band size: 33 kDa
Western blot - Anti-67kDa Laminin Receptor antibody (ab137388)
12% SDS PAGE
All lanes: Western blot - Anti-67kDa Laminin Receptor antibody (ab137388) at 1/1000 dilution
All lanes: Mouse brain whole cell lysate at 50 µg
Predicted band size: 33 kDa
Immunocytochemistry/ Immunofluorescence - Anti-67kDa Laminin Receptor antibody (ab137388)
Immunofluorescence analysis of paraformaldehyde-fixed HeLa cells, labelling 67kDa Laminin Receptor with ab137388 at 1/200 dilution. Lower image is merged with DNA probe.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-67kDa Laminin Receptor antibody (ab137388)
Immunohistochemical analysis of paraffin-embedded Human CA922 xenograft tissue, labelling 67kDa Laminin Receptor with ab137388 at 1/500 dilution.
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