AB137388

Anti-67kDa Laminin Receptor antibody

Name: Anti-67kDa Laminin Receptor antibody (ab137388) | Abcam
Brand: Abcam Limited
SKU: AB137388
Price: 535 USD
Availability: InStock

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(6 Publications)

Rabbit Polyclonal 67kDa Laminin Receptor antibody. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RPSA aa 1 to C-terminus.

View Alternative Names

LAMBR, LAMR1, RPSA, Small ribosomal subunit protein uS2, 37 kDa laminin receptor precursor, 37/67 kDa laminin receptor, 40S ribosomal protein SA, 67 kDa laminin receptor, Colon carcinoma laminin-binding protein, Laminin receptor 1, Laminin-binding protein precursor p40, Multidrug resistance-associated protein MGr1-Ag, NEM/1CHD4, 37LRP, LRP/LR, 67LR, LamR, LBP/p40

5 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-67kDa Laminin Receptor antibody (AB137388)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-67kDa Laminin Receptor antibody (AB137388)

Immunohistochemical analysis of paraffin-embedded Human CA922 xenograft tissue, labelling 67kDa Laminin Receptor with ab137388 at 1/500 dilution.

Supplier Data

Western blot - Anti-67kDa Laminin Receptor antibody (AB137388)

Samples were separated by 10% SDS-PAGE.

All lanes:

Western blot - Anti-67kDa Laminin Receptor antibody (ab137388) at 1/1000 dilution

All lanes:

HepG2 Whole cell extracts at 30 µg

Predicted band size: 33 kDa

false

Supplier Data

Western blot - Anti-67kDa Laminin Receptor antibody (AB137388)

Samples were separated by 12% SDS-PAGE.

All lanes:

Western blot - Anti-67kDa Laminin Receptor antibody (ab137388) at 1/1000 dilution

All lanes:

Jurkat whole cell lysate at 30 µg

Predicted band size: 33 kDa

false

Unknown

Western blot - Anti-67kDa Laminin Receptor antibody (AB137388)

12% SDS PAGE

All lanes:

Western blot - Anti-67kDa Laminin Receptor antibody (ab137388) at 1/1000 dilution

All lanes:

HepG2 whole cell lysate at 30 µg

Predicted band size: 33 kDa

false

Unknown

Western blot - Anti-67kDa Laminin Receptor antibody (AB137388)

12% SDS PAGE

All lanes:

Western blot - Anti-67kDa Laminin Receptor antibody (ab137388) at 1/1000 dilution

All lanes:

Mouse brain whole cell lysate at 50 µg

Predicted band size: 33 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human RPSA aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P08865

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "or Tris-EDTA buffer (pH8.0) Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "" }, "Mouse": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The 67kDa Laminin Receptor also known as the laminin binding protein or protein laminin functions as a receptor for laminin an important component of the extracellular matrix. This receptor is expressed in many tissue types serving an important mechanical role by mediating the adhesion and migration of cells. The receptor anchors cells to laminin molecules thereby influencing cell differentiation and proliferation. The molecular weight of the laminin receptor is approximately 67 kilodaltons which signifies it as a critical player in various cellular processes.

Biological function summary

This receptor engages in cellular interactions that are essential for maintaining the integrity and architecture of tissues. It often associates with other proteins to form complexes which further strengthen its functional capabilities. By anchoring laminin to the cell surface it regulates cell signaling pathways that influence cell motility invasion and survival. These interactions suggest that the 67kDa Laminin Receptor's function goes beyond simple adhesion impacting cellular responsiveness to external matrix cues.

Pathways

The receptor influences the MAPK and PI3K/Akt signaling pathways which are significant in cell survival and proliferation. Through such pathways it interacts with numerous proteins including integrins and fibronectin receptors facilitating orchestrated cell signaling. This connectivity highlights the receptor's role in cellular communication networks contributing to dynamic processes like wound healing and angiogenesis.

Aberrant expression of the 67kDa Laminin Receptor relates to conditions such as cancer and Alzheimer's disease. In cancer its overexpression links to increased tumor invasiveness likely due to enhanced cell motility mediated through integrin interactions. In Alzheimer's disease its relationship with amyloid precursor protein influences plaque formation exacerbating disease progression. Understanding these connections highlights potential therapeutic targets for disease intervention.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA.. (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9.. (Microbial infection) Acts as a receptor for the Dengue virus.. (Microbial infection) Acts as a receptor for the Sindbis virus.. (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus.. (Microbial infection) Acts as a receptor for the pathogenic prion protein.. (Microbial infection) Acts as a receptor for bacteria.

See full target information RPSA

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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

iScience 26:107971 PubMed37810246

2023

Essential role of the amino-terminal region of Drosha for the Microprocessor function.

Applications

Unspecified application

Species

Unspecified reactive species

Amit Prabhakar,Song Hu,Jin Tang,Prajakta Ghatpande,Giorgio Lagna,Xuan Jiang,Akiko Hata

Scientific reports 11:9103 PubMed33907248

2021

(-)-Epigallocatechin-3-gallate induces apoptosis and differentiation in leukaemia by targeting reactive oxygen species and PIN1.

Applications

Unspecified application

Species

Unspecified reactive species

Fernanda Isabel Della Via,Rodrigo Naoto Shiraishi,Irene Santos,Karla Priscila Ferro,Myriam Janeth Salazar-Terreros,Gilberto Carlos Franchi Junior,Eduardo Magalhães Rego,Sara Teresinha Olalla Saad,Cristiane Okuda Torello

Science signaling 14: PubMed33622983

2021

Control of ribosomal protein synthesis by the Microprocessor complex.

Applications

Unspecified application

Species

Unspecified reactive species

Xuan Jiang,Amit Prabhakar,Stephanie M Van der Voorn,Prajakta Ghatpande,Barbara Celona,Srivats Venkataramanan,Lorenzo Calviello,Chuwen Lin,Wanpeng Wang,Brian L Black,Stephen N Floor,Giorgio Lagna,Akiko Hata

International journal of molecular sciences 21: PubMed32028585

2020

AAV-Mediated Gene Delivery to 3D Retinal Organoids Derived from Human Induced Pluripotent Stem Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Marcela Garita-Hernandez,Fiona Routet,Laure Guibbal,Hanen Khabou,Lyes Toualbi,Luisa Riancho,Sacha Reichman,Jens Duebel,Jose-Alain Sahel,Olivier Goureau,Deniz Dalkara

Scientific reports 9:13090 PubMed31511544

2019

Prion protein modulates endothelial to mesenchyme-like transition in trabecular meshwork cells: Implications for primary open angle glaucoma.

Applications

Unspecified application

Species

Unspecified reactive species

Ajay Ashok,Min H Kang,Aaron S Wise,P Pattabiraman,William M Johnson,Michael Lonigro,Ranjana Ravikumar,Douglas J Rhee,Neena Singh

Cell 173:90-103.e19 PubMed29551269

2018

Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis.

Applications

Unspecified application

Species

Unspecified reactive species

Rajiv K Khajuria,Mathias Munschauer,Jacob C Ulirsch,Claudia Fiorini,Leif S Ludwig,Sean K McFarland,Nour J Abdulhay,Harrison Specht,Hasmik Keshishian,D R Mani,Marko Jovanovic,Steven R Ellis,Charles P Fulco,Jesse M Engreitz,Sabina Schütz,John Lian,Karen W Gripp,Olga K Weinberg,Geraldine S Pinkus,Lee Gehrke,Aviv Regev,Eric S Lander,Hanna T Gazda,Winston Y Lee,Vikram G Panse,Steven A Carr,Vijay G Sankaran

View all publications

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Product promise

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For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-67kDa Laminin Receptor antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-67kDa Laminin Receptor antibody (AB137388)

Western blot - Anti-67kDa Laminin Receptor antibody (AB137388)

Western blot - Anti-67kDa Laminin Receptor antibody (AB137388)

Western blot - Anti-67kDa Laminin Receptor antibody (AB137388)

Western blot - Anti-67kDa Laminin Receptor antibody (AB137388)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (6)

Product promise