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AB2280

Anti-8 iso Prostaglandin F2 alpha antibody

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(6 Publications)

Rabbit Polyclonal 8 iso Prostaglandin F2 alpha antibody. Suitable for ELISA, RIA and reacts with Chemical samples. Cited in 6 publications. Immunogen corresponding to Chemical / Small Molecule corresponding to 8 iso Prostaglandin F2 alpha.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Applications

RIA, ELISA

applications

Specificity

This antibody detects PGF1 alpha (33.3%) and PGF2 alpha (1.98%). The antibody will cross-react with 8-iso-Prostaglandin F2 alpha in any species.

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Primary Antibodies

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "RIA" : {"fullname" : "Radioimmunoassay", "shortname":"RIA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Chemical": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "RIA-species-checked": "guaranteed", "RIA-species-dilution-info": "", "RIA-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

8 iso Prostaglandin F2 alpha also known as 8-iso-PGF2α serves as a biomarker for oxidative stress. It belongs to the F2-isoprostanes family which are isomers of prostaglandin F2α. Its molecular mass is noted as approximately 354.5 daltons. 8 iso Prostaglandin F2 alpha is frequently expressed in various tissues and body fluids and is considered a reliable indicator of lipid peroxidation in the body.
Biological function summary

This compound acts as a signaling molecule involved in cellular processes related to oxidative stress. It does not form part of a large complex but influences cellular functions during stress conditions. By reflecting levels of oxidative damage in tissues it plays a significant role in understanding the body's response to free radicals and related challenges it encounters.

Pathways

8 iso Prostaglandin F2 alpha participates as a part of the arachidonic acid metabolism. It has relevance in the oxidative stress pathway by interacting with different enzymes related to prostaglandin synthesis. Importantly it operates alongside proteins like cyclooxygenase although it results from non-enzymatic reactions illustrating its distinct yet interconnected function in pathways governing oxidative stress responses.

8 iso Prostaglandin F2 alpha sees association with conditions such as cardiovascular diseases and neurodegenerative disorders like Alzheimer's disease. Its formation links to increased oxidative stress marking its relation to these diseases. Studies have noticed connections with proteins such as amyloid-beta in Alzheimer's providing evidence for its role in monitoring disease progression impacted by oxidative damage.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information 8 iso Prostaglandin F2 alpha
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

eLife 11: PubMed36107481

2022

Murine blastocysts generated by in vitro fertilization show increased Warburg metabolism and altered lactate production.

Applications

Unspecified application

Species

Unspecified reactive species

Seok Hee Lee,Xiaowei Liu,David Jimenez-Morales,Paolo F Rinaudo

Biology of reproduction 100:1090-1107 PubMed30418487

2018

Depletion of thiols leads to redox deregulation, production of 4-hydroxinonenal and sperm senescence: a possible role for GSH regulation in spermatozoa†.

Applications

Unspecified application

Species

Unspecified reactive species

Cristina Ortega-Ferrusola,Patricia Martin Muñoz,Jose Manuel Ortiz-Rodriguez,Luis Anel-López,Carolina Balao da Silva,Mercedes Álvarez,Paulino de Paz,Jose Antonio Tapia,Luis Anel,Antonio Silva-Rodríguez,Robert J Aitken,M Cruz Gil,Zamira Gibb,Fernando J Peña

Reproduction in domestic animals = Zuchthygiene 53:54-67 PubMed28833663

2017

Redox cycling induces spermptosis and necrosis in stallion spermatozoa while the hydroxyl radical (OH•) only induces spermptosis.

Applications

Unspecified application

Species

Unspecified reactive species

P Martín Muñoz,L Anel-López,J M Ortiz-Rodríguez,M Álvarez,P de Paz,C Balao da Silva,H Rodríguez Martinez,M C Gil,L Anel,F J Peña,C Ortega Ferrusola

Neurobiology of disease 68:66-77 PubMed24769161

2014

Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome.

Applications

IHC-P

Species

Mouse

Claudio De Felice,Floriana Della Ragione,Cinzia Signorini,Silvia Leoncini,Alessandra Pecorelli,Lucia Ciccoli,Francesco Scalabrì,Federico Marracino,Michele Madonna,Giuseppe Belmonte,Laura Ricceri,Bianca De Filippis,Giovanni Laviola,Giuseppe Valacchi,Thierry Durand,Jean-Marie Galano,Camille Oger,Alexandre Guy,Valérie Bultel-Poncé,Jacky Guy,Stefania Filosa,Joussef Hayek,Maurizio D'Esposito

European journal of cardio-thoracic surgery : offi 43:1154-63 PubMed23209276

2012

Acetylsalicylic acid treatment until surgery reduces oxidative stress and inflammation in patients undergoing coronary artery bypass grafting.

Applications

IHC-Fr

Species

Unspecified reactive species

Kirsti Berg,Mette Langaas,Madelene Ericsson,Hilde Pleym,Samar Basu,Ivar Skjåk Nordrum,Nicola Vitale,Rune Haaverstad

Molecular vision 13:190-5 PubMed17327824

2007

Isoprostane F2alpha-VI, a new marker of oxidative stress, increases following light damage to the mouse retina.

Applications

IHC-Fr

Species

Unspecified reactive species

Tzvete Dentchev,Yuemang Yao,Domenico Pratico,Joshua Dunaief
View all publications
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Product promise

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