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Rabbit Polyclonal A1BG antibody. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Mouse A1bg aa 300 to C-terminus.

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Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-A1BG antibody (AB231805), expandable thumbnail
  • Western blot - Anti-A1BG antibody (AB231805), expandable thumbnail
  • Western blot - Anti-A1BG antibody (AB231805), expandable thumbnail

Publications

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 55.77% Glycerol (glycerin, glycerine), 44.12% PBS

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Mouse A1bg aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q19LI2

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-P
Mouse
Tested
Tested

Tested
Tested

Species

Mouse

Dilution info

0.2-2 µg/mL

Notes

-

Tested
Tested

Species

Mouse

Dilution info

5-20 µg/mL

Notes

-

Associated Products

Select an associated product type

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Alternative names

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Rabbit Polyclonal A1BG antibody. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Mouse A1bg aa 300 to C-terminus.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Mouse A1bg aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q19LI2
Purification technique

Affinity purification Immunogen

Concentration
Loading...
Purification notes

Followed by Protein A affinity chromatography.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

A1BG also known as alpha-1-B glycoprotein is a plasma protein with a mass of approximately 63 kDa. It demonstrates expression prominently in the liver and circulates in the bloodstream. The gene coding for A1BG is located on chromosome 19. A1BG does not seem to have enzymatic activity but instead acts as a carrier protein interacting with other molecules to modulate their stability and availability in plasma.

Biological function summary

The function of A1BG involves interaction with cysteine proteinase inhibitors though it is not part of any known large protein complex. It participates in the regulation of protease activity by sequestering inhibitors from the active site of proteases. This regulation plays a role in maintaining balanced proteolytic activity in tissues which is important for processes such as inflammation and tissue remodeling.

Pathways

A1BG is involved in metabolic processes of extracellular proteins. The protein does not interact directly with major signaling pathways but it influences them indirectly by modulating enzymatic activity. A1BG interacts with alpha-2-macroglobulin which is part of the protease inhibitor category and is also involved in the immune response. This relationship impacts the bioavailability and activity of various cytokines and growth factors affecting pathways like inflammation control and extracellular matrix organization.

Associated diseases and disorders

A1BG levels show association with conditions like cancer and neurodegenerative diseases. Observed in certain cancers altered A1BG expression might influence tumor growth and metastasis. In neurodegenerative disorders such as Alzheimer's disease the protein's interaction with protease inhibitors could potentially affect amyloid-beta processing. The interaction between A1BG and alpha-2-macroglobulin is significant as dysregulation in this association may contribute to the disease pathogenesis.

Product promise

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3 product images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-A1BG antibody (ab231805), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-A1BG antibody (ab231805)

    Formalin-fixed, paraffin-embedded mouse liver tissue stained for A1BG using ab231805 at 20 μg/mL in immunohistochemical analysis. DAB staining.

  • Western blot - Anti-A1BG antibody (ab231805), expandable thumbnail

    Western blot - Anti-A1BG antibody (ab231805)

    All lanes: Western blot - Anti-A1BG antibody (ab231805) at 1 µg/mL

    All lanes: Mouse liver lysate

    Predicted band size: 54 kDa

  • Western blot - Anti-A1BG antibody (ab231805), expandable thumbnail

    Western blot - Anti-A1BG antibody (ab231805)

    All lanes: Western blot - Anti-A1BG antibody (ab231805) at 1 µg/mL

    All lanes: Recombinant mouse A1BG protein

    Developed using the ECL technique.

    Predicted band size: 54 kDa

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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