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AB197367

Anti-AARS2 antibody

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(1 Publication)

Rabbit Polyclonal AARS2 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Fusion protein corresponding to AARS2, fused to AARS2.

View Alternative Names

AARSL, KIAA1270, AARS2, Alanyl-tRNA synthetase, AlaRS

1 Images
Western blot - Anti-AARS2 antibody (AB197367)
  • WB

Supplier Data

Western blot - Anti-AARS2 antibody (AB197367)

Gel : 8%SDS-PAGE

All lanes:

Western blot - Anti-AARS2 antibody (ab197367) at 1/600 dilution

All lanes:

SP20 cell lysate at 40 µg

Predicted band size: 107 kDa

true

Exposure time: 15s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Fusion protein corresponding to AARS2, fused to AARS2. The exact immunogen used to generate this antibody is proprietary information.

Q5JTZ9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AARS2 also known as alanyl-tRNA synthetase 2 is an important enzyme encoded by the AARS2 gene. This protein has a molecular mass of approximately 107 kDa. It participates in the charging of tRNA with alanine a process necessary for protein synthesis. AARS2 localizes mainly in the mitochondria and is expressed in various tissues including the heart skeletal muscle and liver.
Biological function summary

AARS2 plays an important role in maintaining mitochondrial protein translation by ensuring the correct tRNA is available for mitochondrial proteins. It is part of the larger aminoacyl-tRNA synthetase complex which is important for accurate mRNA translation in the cell. Proper functioning of AARS2 ensures that proteins essential for mitochondrial activity are correctly synthesized and function optimally.

Pathways

AARS2 is integral in mitochondrial translation pathways and links to broader oxidative phosphorylation. These pathways are critical for energy production within the cell. AARS2 interacts with other mitochondrial aminoacyl-tRNA synthetases and proteins involved in oxidative phosphorylation like NDUFA4 which is part of the electron transport chain.

Mutations in AARS2 can lead to mitochondrial myopathy and leukoencephalopathy. These conditions arise due to defects in mitochondrial protein translation or function affecting tissues with high energy demand. AARS2 mutations may involve interactions with proteins like POLG a mitochondrial DNA polymerase which also plays a role in maintaining mitochondrial DNA integrity aggravating the disease phenotypes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction : alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
See full target information AARS2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Human molecular genetics 28:258-268 PubMed30285085

2018

Instability of the mitochondrial alanyl-tRNA synthetase underlies fatal infantile-onset cardiomyopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Ewen W Sommerville,Xiao-Long Zhou,Monika Oláhová,Janda Jenkins,Liliya Euro,Svetlana Konovalova,Taru Hilander,Angela Pyle,Langping He,Sultan Habeebu,Carol Saunders,Anna Kelsey,Andrew A M Morris,Robert McFarland,Anu Suomalainen,Gráinne S Gorman,En-Duo Wang,Isabelle Thiffault,Henna Tyynismaa,Robert W Taylor
View all publications
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