Anti-AATF/DED antibody [3C7]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

AATF also known as apoptosis antagonizing transcription factor and sometimes referred to as DED a.k.a. death effector detach protein is a pivotal regulator of cellular processes. This protein has a molecular mass of approximately 61 kDa. AATF is expressed in various tissues including the brain and liver where it plays a diverse role in cellular function. As an antagonist of apoptosis AATF interacts with signaling pathways to modulate cell survival and proliferation.

Biological function summary

The protein is involved in numerous cellular activities such as transcriptional regulation and cell cycle control. AATF associates with nucleoprotein complexes and is critical in regulating transcription by interacting with RNA polymerase II. It acts as a transcriptional co-regulator influencing genes responsible for cell growth and survival. Research indicates that AATF can affect the balance between cell survival and death which is significant in both development and response to cellular stress.

Pathways

AATF interacts with multiple signaling cascades notably the apoptosis and cell cycle pathways. For example AATF participates in the p53 pathway influencing cellular responses to DNA damage. It interacts with other proteins such as p21 and cyclin D1 helping to modulate cell cycle progression and ensuring genomic stability. These interactions highlight AATF's role in maintaining cellular homeostasis and regulating programmed cell death processes.

Associated diseases and disorders

AATF is associated with cancer and neurodegenerative diseases. Its ability to inhibit apoptosis and regulate cell proliferation links it to tumorigenesis. In cancer AATF's interaction with proteins like Bcl-2 can prevent the initiation of apoptosis contributing to tumor cell survival. Additionally imbalance in AATF activity may influence the progression of neurodegenerative conditions where its regulatory role on apoptosis and cell cycle can affect neuronal survival and function.