AB231529

Anti-AATK antibody

Name: Anti-AATK antibody (ab231529) | Abcam
Brand: Abcam Limited
SKU: AB231529
Price: 525 USD
Availability: InStock

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(1 Publication)

Rabbit Polyclonal AATK antibody. Suitable for WB, IHC-P and reacts with Mouse, Recombinant full length protein - Human, Rat, Pig, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human AATK aa 1200 to C-terminus.

View Alternative Names

AATYK, KIAA0641, LMR1, LMTK1, AATK, Serine/threonine-protein kinase LMTK1, Apoptosis-associated tyrosine kinase, Brain apoptosis-associated tyrosine kinase, CDK5-binding protein, Lemur tyrosine kinase 1, p35-binding protein, p35BP

7 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AATK antibody (AB231529)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AATK antibody (AB231529)

Paraffin-embedded human prostate gland tissue stained for AATK using ab231529 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AATK antibody (AB231529)

Paraffin-embedded human liver tissue stained for AATK using ab231529 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AATK antibody (AB231529)

Paraffin-embedded human kidney tissue stained for AATK using ab231529 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AATK antibody (AB231529)

Paraffin-embedded human pancreatic cancer tissue stained for AATK using ab231529 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AATK antibody (AB231529)

Paraffin-embedded human stomach cancer tissue stained for AATK using ab231529 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-AATK antibody (AB231529)

All lanes:

Western blot - Anti-AATK antibody (ab231529) at 3 µg/mL

Lane 1:

Mouse brain lysate

Lane 2:

Rat brain lysate

Lane 3:

Pig brain lysate

Secondary

All lanes:

HRP-linked guinea pig anti-rabbit at 1/2000 dilution

Predicted band size: 145 kDa

false

Supplier Data

Western blot - Anti-AATK antibody (AB231529)

All lanes:

Western blot - Anti-AATK antibody (ab231529) at 3 µg/mL

All lanes:

Recombinant human AATK protein

Secondary

All lanes:

HRP-linked guinea pig anti-rabbit at 1/2000 dilution

Predicted band size: 145 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat, Human, Pig

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human AATK aa 1200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q6ZMQ8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Recombinant full length protein - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

ab231529 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AATK also known as Apoptosis-Associated Tyrosine Kinase functions mechanically as a kinase that contains a domain for kinase activity. It has a molecular mass of approximately 165 kDa. Researchers have found AATK expression across various tissues notably in the nervous system. This wide expression suggests its involvement in critical cellular processes.

Biological function summary

AATK influences the regulation of apoptosis and promotes neurite outgrowth. It does not appear to be part of a larger protein complex. In neurons AATK participates in processes that control cell death and differentiation which indicates its role in neuronal development and function.

Pathways

AATK plays roles in the apoptosis signaling and neuronal differentiation pathways. These pathways integrate signals to guide cellular fate decisions. AATK interacts with proteins like p53 and other kinases that are well-known in regulating cell cycle and apoptotic processes.

AATK has associations with neurodegenerative diseases including Alzheimer's disease as well as some types of cancer. It shares connections with proteins such as tau in Alzheimer's where defective apoptosis and cell signaling contribute to pathological states. Further research into AATK may offer insights into therapeutic strategies for these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

May be involved in neuronal differentiation.

See full target information AATK

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical investigation 131: PubMed34499625

2021

Recipient APOL1 risk alleles associate with death-censored renal allograft survival and rejection episodes.

Applications

Unspecified application

Species

Unspecified reactive species

Zhongyang Zhang,Zeguo Sun,Jia Fu,Qisheng Lin,Khadija Banu,Kinsuk Chauhan,Marina Planoutene,Chengguo Wei,Fadi Salem,Zhengzi Yi,Ruijie Liu,Paolo Cravedi,Haoxiang Cheng,Ke Hao,Philip J O'Connell,Shuta Ishibe,Weijia Zhang,Steven G Coca,Ian W Gibson,Robert B Colvin,John Cijiang He,Peter S Heeger,Barbara Murphy,Madhav C Menon

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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