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AB231535

Anti-ABCB10 antibody

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(3 Publications)

Rabbit Polyclonal ABCB10 antibody. Suitable for WB, IHC-P and reacts with Pig, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ABCB10 aa 450 to C-terminus.

View Alternative Names

ABC-mitochondrial erythroid protein, ATP-binding cassette transporter 10, Mitochondrial ATP-binding cassette 2, ABC-me protein, ABC transporter 10 protein, M-ABC2, ABCB10

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABCB10 antibody (AB231535)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABCB10 antibody (AB231535)

Formalin-fixed, paraffin-embedded human liver tissue stained for ABCB10 using ab231535 at 20μg/ml in immunohistochemical analysis. DAb staining.

Western blot - Anti-ABCB10 antibody (AB231535)
  • WB

Supplier Data

Western blot - Anti-ABCB10 antibody (AB231535)

All lanes:

Western blot - Anti-ABCB10 antibody (ab231535) at 2 µg/mL

All lanes:

Pig liver lysate

Predicted band size: 79 kDa

false

Western blot - Anti-ABCB10 antibody (AB231535)
  • WB

Supplier Data

Western blot - Anti-ABCB10 antibody (AB231535)

All lanes:

Western blot - Anti-ABCB10 antibody (ab231535) at 2 µg/mL

All lanes:

Recombinant human ABCB10 protein.

Predicted band size: 79 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Pig

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ABCB10 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9NRK6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab231535 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ABCB10 also known as ATP-binding cassette sub-family B member 10 plays a role as a transport protein involved in the mitochondrial export of molecules. It is a member of the ABC (ATP-binding cassette) transporter family characterized by its ability to move various substrates across membranes using ATP hydrolysis. ABCB10 has a molecular mass of approximately 81 kDa and is expressed mainly in the mitochondria of cells with significant levels in tissues with high metabolic activity like the heart and liver.
Biological function summary

ABCB10 contributes to important cellular functions by participating in heme synthesis. It interacts with other mitochondrial proteins forming complexes that facilitate the import of iron and export of heme precursors. This interaction ensures the maintenance of proper heme levels which are necessary for diverse cellular processes including respiration and detoxification pathways. Its activity is not isolated but connected to broader protein networks within the mitochondrial intermembrane space.

Pathways

ABCB10 participates in the heme biosynthesis pathway which is essential for the production of hemoproteins including hemoglobin and cytochromes. Within this context ABCB10 works closely with proteins such as ferrochelatase which catalyzes the final step in heme production. Another related pathway is oxidative phosphorylation where ABCB10 indirectly sustains energy production by ensuring the availability of heme for cytochrome assembly which is pivotal for electron transport chain function.

ABCB10 plays a significant role in conditions related to mitochondrial dysfunction such as sideroblastic anemia and cardiovascular diseases. Mutations affecting ABCB10 can disrupt normal heme synthesis impacting red blood cell production and leading to anemia. Additionally improper function of ABCB10 influences iron homeostasis which associates with proteins like ALAS2 (aminolevulinate synthase 2) further contributing to erythropoietic disorders and highlighting its role in iron-related pathologies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

ATP-dependent transporter located in the mitochondrial inner membrane that catalyzes the export of biliverdin from the mitochondrial matrix, and plays a crucial role in hemoglobin synthesis and antioxidative stress (PubMed : 22085049, PubMed : 28315685, PubMed : 28808058, PubMed : 34011630, PubMed : 37041204). Participates in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX) (PubMed : 22085049, PubMed : 28808058). Involved in the stabilization of the iron transporter mitoferrin-1/SLC25A37 (By similarity). In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria (PubMed : 28315685).
See full target information ABCB10
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Antioxidants (Basel, Switzerland) 10: PubMed34943057

2021

Mito-TIPTP Increases Mitochondrial Function by Repressing the Rubicon-p22phox Interaction in Colitis-Induced Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jae-Sung Kim,Ye-Ram Kim,Sein Jang,Sang Geon Wang,Euni Cho,Seok-Jun Mun,Hye-In Jeon,Hyo-Keun Kim,Sun-Joon Min,Chul-Su Yang

Frontiers in cell and developmental biology 9:688070 PubMed34386493

2021

Surface PEGylated Cancer Cell Membrane-Coated Nanoparticles for Codelivery of Curcumin and Doxorubicin for the Treatment of Multidrug Resistant Esophageal Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Gao,Yue Zhu,Xiaopeng Xu,Fangjun Wang,Weidong Shen,Xia Leng,Jiyi Zhao,Bingtuan Liu,Yangyun Wang,Pengfei Liu

Drug development research 82:115-122 PubMed32820830

2020

The involvement of protein TNFSF18 in promoting p-STAT1 phosphorylation to induce coronary microcirculation disturbance in atherosclerotic mouse model.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Gao,Sai Wang,Shilei Liu
View all publications
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