AB197406

Anti-ABCB5 antibody

Name: Anti-ABCB5 antibody (ab197406) | Abcam
Brand: Abcam Limited
SKU: AB197406
Price: 535 USD
Availability: InStock

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(1 Publication)

Rabbit Polyclonal ABCB5 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ATP-binding cassette sub-family B member 5.

View Alternative Names

ATP-binding cassette sub-family B member 5, ABCB5 P-gp, P-glycoprotein ABCB5, ABCB5

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABCB5 antibody (AB197406)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABCB5 antibody (AB197406)

Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue labeling ABCB5 with ab197406 at a 1/10 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABCB5 antibody (AB197406)

Immunohistochemical analysis of paraffin-embedded human renal cancer tissue labeling ABCB5 with ab197406 at a 1/10 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ATP-binding cassette sub-family B member 5. The exact immunogen used to generate this antibody is proprietary information.

Q2M3G0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/10 - 1/50", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ABCB5 also known as ATP-binding cassette sub-family B member 5 belongs to the ABC transporter family. This protein functions mechanically as a transmembrane transporter that moves various molecules across cellular membranes using ATP hydrolysis. ABCB5 has a molecular mass of approximately 81 kDa. It is primarily expressed in stem cells melanocytes and certain cancer cells notably in the skin and eye tissues.

Biological function summary

ABCB5 plays an essential role in the regulation of cellular processes including development proliferation and differentiation. It is part of the ATP-binding cassette transporters which help in maintaining cellular homeostasis by exporting toxic substances out of cells. In stem cells ABCB5 maintains the undifferentiated state and protects cells from apoptosis by mediating efflux of drugs contributing to multidrug resistance.

Pathways

ABCB5 interacts with several cellular pathways involved in cell survival and drug resistance. It is closely connected with the Wnt/beta-catenin signaling pathway which regulates cell proliferation and differentiation. ABCB5 also interacts with proteins like P-glycoprotein (ABCB1) as they both participate in similar drug resistance mechanisms affecting therapeutic outcomes in cancer treatment.

Research links ABCB5 to cancer progression and treatment resistance especially in melanoma and colorectal cancer. Its overexpression associates with chemotherapy resistance indicating a need for targeted therapy approaches. In melanoma proteins such as CD133 and ABCB5 together contribute to maintaining cancer stem cell populations which can lead to metastasis and recurrence.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells (PubMed : 12960149, PubMed : 15205344, PubMed : 15899824, PubMed : 22306008). Specifically present in limbal stem cells, where it plays a key role in corneal development and repair (By similarity).

See full target information ATP-binding cassette sub-family B member 5

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell journal 24:665-672 PubMed36377216

2022

Long Non-Coding RNA Functions as A Tumor Suppressor in Colorectal Cancer via Modulating The Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Liumin Kang,Jie Sun,Jie Liu,Feng Xu,Qilin Zhu,Xiaohua Shi

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ABCB5 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABCB5 antibody (AB197406)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABCB5 antibody (AB197406)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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