JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB91451

Anti-ABCC10 antibody [M7I-3]

Be the first to review this product! Submit a review

|

(8 Publications)

Rat Monoclonal ABCC10 antibody. Suitable for ICC and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ABCC10 aa 150-300.

View Alternative Names

MRP7, SIMRP7, ABCC10, ATP-binding cassette sub-family C member 10, Multidrug resistance-associated protein 7

1 Images
Immunocytochemistry - Anti-ABCC10 antibody [M7I-3] (AB91451)
  • ICC

Unknown

Immunocytochemistry - Anti-ABCC10 antibody [M7I-3] (AB91451)

ab91451 at 1/20 dilution staining ABCC10 in ABCC10 transfected HEK cells by Immunocytochemistry.

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

M7I-3

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC

applications

Immunogen

Recombinant Fragment Protein within Human ABCC10 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.

Q5T3U5

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "1/20 - 1/50", "ICC-species-notes": "<p>Acetone fixed cytospin preparations.</p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.3 Preservative: 0.1% Sodium azide Constituents: 0.7% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The ABCC10 protein also known as Multidrug Resistance Protein 7 (MRP7) functions as an ATP-binding cassette transporter. It contributes to multidrug resistance by extruding a variety of xenobiotics and physiological substrates out of cells. The ABCC10 protein has a mass of about 171 kDa. Researchers have found ABCC10 expression in various tissues including the liver lung and testis suggesting its diverse role in different cell types.
Biological function summary

This transporter plays critical roles in cellular detoxification processes. ABCC10 is part of the larger ATP-binding cassette (ABC) transporter family which includes other transporters like ABCC1 and ABCC2. By actively transporting drugs and organic anions across cellular membranes ABCC10 helps regulate the intracellular concentrations of these compounds and maintain cellular homeostasis.

Pathways

ABCC10 participates in the detoxification and xenobiotic metabolism pathways interacting with enzymes such as cytochrome P450s. The protein contributes to the resistance against various chemotherapy drugs by exporting them out of cells impacting the drug metabolism pathway. This function is related to other ABC transporters like ABCC1 which similarly influence drug clearance and pharmacokinetics.

ABCC10 has been implicated in cancer chemotherapy resistance. Many studies have noted that overexpression of ABCC10 correlates with reduced drug accumulation in cancer cells resulting in chemotherapy failure. Its function is also connected to the protein P-glycoprotein another drug transporter that plays a similar role in multidrug resistance highlighting the complex network of transporters involved in therapeutic resistance.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed : 12527806, PubMed : 15256465). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs, such as, docetaxel and paclitaxel (PubMed : 15256465, PubMed : 23087055). Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP (PubMed : 12527806).
See full target information ABCC10
style
left-column

Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in endocrinology 11:566761 PubMed33362712

2020

SDF-1α/MicroRNA-134 Axis Regulates Nonfunctioning Pituitary Neuroendocrine Tumor Growth Targeting VEGFA.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyu Wang,Yuanjian Fang,Yunxiang Zhou,Xiaoming Guo,Ke Xu,Chenguang Li,Jianmin Zhang,Yuan Hong

Oncology letters 20:148 PubMed32934716

2020

Effect of sodium butyrate on ABC transporters in lung cancer A549 and colorectal cancer HCT116 cells.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Shi,Fang-Fang Xu,Cai-Ping Xiang,Ru Jia,Chun-Hong Yan,Se-Qing Ma,Ning Wang,An-Jiao Wang,Ping Fan

Oncology research 28:423-438 PubMed32331534

2020

The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Wei,Xiao-Dong Ma,Guan-Min Jiang,Bin Shi,Wen Zhong,Chun-Lei Sun,Liang Zhao,Yan-Jiao Hou,Hao Wang

Oncology letters 18:4064-4073 PubMed31579069

2019

miR-361 enhances sensitivity to 5-fluorouracil by targeting the FOXM1-ABCC5/10 signaling pathway in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Luyao Zhang,Bo Li,Beilin Zhang,Hua Zhang,Jian Suo

Archives of medical science : AMS 15:1539-1546 PubMed31749883

2019

Long non-coding RNA FOXF1 adjacent non-coding developmental regulatory RNA inhibits growth and chemotherapy resistance in non-small cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ran Xu,Yun Han

Oncology letters 18:63-71 PubMed31289473

2019

Effects of histone deacetylase inhibitors on ATP-binding cassette transporters in lung cancer A549 and colorectal cancer HCT116 cells.

Applications

Unspecified application

Species

Unspecified reactive species

Hao Wang,Chun-Hua Chi,Ying Zhang,Bin Shi,Ru Jia,Ben-Jun Wang

Asian journal of andrology 21:460-467 PubMed30880686

2019

The transcription factor ZEB1 promotes chemoresistance in prostate cancer cell lines.

Applications

Unspecified application

Species

Unspecified reactive species

Octavio Orellana-Serradell,Daniela Herrera,Enrique A Castellón,Héctor R Contreras

Molecular cancer therapeutics 10:1289-99 PubMed21551263

2011

Chemotherapy dosing schedule influences drug resistance development in ovarian cancer.

Applications

WB

Species

Mouse

Raquel De Souza,Payam Zahedi,Rose M Badame,Christine Allen,Micheline Piquette-Miller
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB69296

Anti-ABCC10 antibody

Western blot - Anti-ABCC10 antibody (AB69296)

  • 0
  • 0

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB3375

Anti-MRP3 antibody [M3II-9]

Functional Studies - Anti-MRP3 antibody [M3II-9] (AB3375)

  • 4
  • 3
Primary Antibodies

AB189524

Anti-CD44 antibody [EPR18668]

RabMAb|Recombinant|Lab Essentials|20ul selling size|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD44 antibody [EPR18668] (AB189524)

  • 5
  • 1
Primary Antibodies

AB81299

Anti-gamma H2A.X (phospho S139) antibody [EP854(2)Y]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-gamma H2A.X (phospho S139) antibody [EP854(2)Y] (AB81299)

  • 4
  • 17

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com