Rat Monoclonal ABCC10 antibody. Suitable for ICC and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ABCC10 aa 150-300.
Images
![Immunocytochemistry - Anti-ABCC10 antibody [M7I-3] (AB91451), expandable thumbnail](https://content.abcam.com/products/images/abcc10-antibody-m7i-3-ab91451--immunocytochemistry-img111357.jpg/_jcr_content/renditions/webp-475.webp "Immunocytochemistry - Anti-ABCC10 antibody [M7I-3] (AB91451)")
Publications
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- Frontiers in endocrinology 11:5667612020SDF-1α/MicroRNA-134 Axis Regulates Nonfunctioning Pituitary Neuroendocrine Tumor Growth Targeting VEGFA.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaoyu Wang et. al.PubMed 33362712
- Oncology letters 20:1482020Effect of sodium butyrate on ABC transporters in lung cancer A549 and colorectal cancer HCT116 cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBin Shi et. al.PubMed 32934716
- Oncology research 28:423-4382020The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWei Wei et. al.PubMed 32331534
- Oncology letters 18:4064-40732019miR-361 enhances sensitivity to 5-fluorouracil by targeting the FOXM1-ABCC5/10 signaling pathway in colorectal cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLuyao Zhang,Bo Li,Beilin Zhang,Hua Zhang,Jian SuoPubMed 31579069
- Archives of medical science : AMS 15:1539-15462019Long non-coding RNA FOXF1 adjacent non-coding developmental regulatory RNA inhibits growth and chemotherapy resistance in non-small cell lung cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRan Xu et. al.PubMed 31749883
- Oncology letters 18:63-712019Effects of histone deacetylase inhibitors on ATP-binding cassette transporters in lung cancer A549 and colorectal cancer HCT116 cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHao Wang et. al.PubMed 31289473
- Asian journal of andrology 21:460-4672019The transcription factor ZEB1 promotes chemoresistance in prostate cancer cell lines.Applications:Unspecified applicationReactive species:Unspecified reactive speciesOctavio Orellana-Serradell,Daniela Herrera,Enrique A Castellón,Héctor R ContrerasPubMed 30880686
- Molecular cancer therapeutics 10:1289-992011Chemotherapy dosing schedule influences drug resistance development in ovarian cancer.
Key facts
- Isotype
- IgG
- Host species
- Rat
- Storage buffer
pH: 7.3
Preservative: 0.1% Sodium azide
Constituents: 0.7% BSA- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- Recombinant Fragment Protein within Human ABCC10 aa 150-300. The exact immunogen used to generate this antibody is proprietary information. Database link Q5T3U5
Reactivity data
Select an application| ICC | |
|---|---|
| Human | Tested |
ICC
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/20.00000 - 1/50.00000 | Notes Acetone fixed cytospin preparations. |
Associated Products
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1 product for Alternative Product
Target data
Function
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:12527806, PubMed:15256465). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs, such as, docetaxel and paclitaxel (PubMed:15256465, PubMed:23087055). Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP (PubMed:12527806).
Alternative names
MRP7, SIMRP7, ABCC10, ATP-binding cassette sub-family C member 10, Multidrug resistance-associated protein 7
Recommended products
Rat Monoclonal ABCC10 antibody. Suitable for ICC and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ABCC10 aa 150-300.
Key facts
- Isotype
- IgG
- Host species
- Rat
- Storage buffer
pH: 7.3
Preservative: 0.1% Sodium azide
Constituents: 0.7% BSA- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- Recombinant Fragment Protein within Human ABCC10 aa 150-300. The exact immunogen used to generate this antibody is proprietary information. Database link Q5T3U5
- Clone number
- M7I-3
- Purity
- Tissue culture supernatant
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The ABCC10 protein also known as Multidrug Resistance Protein 7 (MRP7) functions as an ATP-binding cassette transporter. It contributes to multidrug resistance by extruding a variety of xenobiotics and physiological substrates out of cells. The ABCC10 protein has a mass of about 171 kDa. Researchers have found ABCC10 expression in various tissues including the liver lung and testis suggesting its diverse role in different cell types.
- Biological function summary
This transporter plays critical roles in cellular detoxification processes. ABCC10 is part of the larger ATP-binding cassette (ABC) transporter family which includes other transporters like ABCC1 and ABCC2. By actively transporting drugs and organic anions across cellular membranes ABCC10 helps regulate the intracellular concentrations of these compounds and maintain cellular homeostasis.
- Pathways
ABCC10 participates in the detoxification and xenobiotic metabolism pathways interacting with enzymes such as cytochrome P450s. The protein contributes to the resistance against various chemotherapy drugs by exporting them out of cells impacting the drug metabolism pathway. This function is related to other ABC transporters like ABCC1 which similarly influence drug clearance and pharmacokinetics.
- Associated diseases and disorders
ABCC10 has been implicated in cancer chemotherapy resistance. Many studies have noted that overexpression of ABCC10 correlates with reduced drug accumulation in cancer cells resulting in chemotherapy failure. Its function is also connected to the protein P-glycoprotein another drug transporter that plays a similar role in multidrug resistance highlighting the complex network of transporters involved in therapeutic resistance.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
![Immunocytochemistry - Anti-ABCC10 antibody [M7I-3] (ab91451), expandable thumbnail](https://content.abcam.com/products/images/abcc10-antibody-m7i-3-ab91451--immunocytochemistry-img111357.jpg "Immunocytochemistry - Anti-ABCC10 antibody [M7I-3] (ab91451)")
Immunocytochemistry - Anti-ABCC10 antibody [M7I-3] (ab91451)
ab91451 at 1/20 dilution staining ABCC10 in ABCC10 transfected HEK cells by Immunocytochemistry.
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