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AB91453

Anti-ABCC12 antibody [M9I-38]

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(3 Publications)

Rat Monoclonal ABCC12 antibody. Suitable for ICC, WB, IHC-Fr and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ABCC12 aa 1-50.

View Alternative Names

MRP9, ABCC12, ATP-binding cassette sub-family C member 12, Multidrug resistance-associated protein 9

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

M9I-38

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC, WB, IHC-Fr

applications

Immunogen

Recombinant Fragment Protein within Human ABCC12 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q96J65

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.3 Preservative: 0.1% Sodium azide Constituents: 0.7% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ABCC12 also known as ATP-binding cassette sub-family C member 12 is a protein that functions as a transporter. It belongs to the superfamily of ABC (ATP-binding cassette) transporters. The protein is encoded by the ABCC12 gene and has a molecular mass of approximately 174 kDa. ABCC12 expresses itself in various tissues including the brain testis and other cellular locations. Its expression patterns suggest a role in mediating the movement of molecules across cellular membranes though the complete spectrum of substrates for ABCC12 remains under investigation.
Biological function summary

ABCC12 works as a transporter moving endogenous and xenobiotic substances across biological membranes. It is not part of a well-characterized complex but it shares functional similarities with other members of the ABC transporter family. These proteins contribute to the cellular processes such as detoxification and the maintenance of cellular homeostasis. Researchers have noticed that alterations in ABCC12 expression can have impacts on cellular resistance to certain drugs suggesting a protective role in different cell types.

Pathways

ABCC12 is involved in the processes related to the movement of lipophilic anions and peptides. It is connected with the ABC transporter pathway which is critical in the metabolism and transport of molecules in and out of cells. ABCC12 interacts with proteins related to the multi-drug resistance pathway such as other ABC family members like ABCC1. These pathways highlight its involvement in cellular defense mechanisms against environmental toxins and metabolic waste products.

Mutations or malfunctions in ABCC12 have been linked to specific health conditions although direct links are still being explored. Studies suggest potential involvement in certain cancer types due to its role in drug resistance making it a potential target for therapeutic intervention. Furthermore it may have implications in neurological disorders given its expression in brain tissue and its related proteins in the ABC family such as ABCC8 which have established roles in insulin secretion and neuronal activity. Continued research seeks to clarify the specific contribution of ABCC12 in these contexts.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Probable transporter, its substrate specificity is unknown.
See full target information ABCC12
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 20:148 PubMed32934716

2020

Effect of sodium butyrate on ABC transporters in lung cancer A549 and colorectal cancer HCT116 cells.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Shi,Fang-Fang Xu,Cai-Ping Xiang,Ru Jia,Chun-Hong Yan,Se-Qing Ma,Ning Wang,An-Jiao Wang,Ping Fan

Oncology research 28:423-438 PubMed32331534

2020

The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Wei,Xiao-Dong Ma,Guan-Min Jiang,Bin Shi,Wen Zhong,Chun-Lei Sun,Liang Zhao,Yan-Jiao Hou,Hao Wang

Oncology letters 18:63-71 PubMed31289473

2019

Effects of histone deacetylase inhibitors on ATP-binding cassette transporters in lung cancer A549 and colorectal cancer HCT116 cells.

Applications

Unspecified application

Species

Unspecified reactive species

Hao Wang,Chun-Hua Chi,Ying Zhang,Bin Shi,Ru Jia,Ben-Jun Wang
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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