Rabbit Polyclonal ABCD2 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human ABCD2 aa 300-600.
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Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human ABCD2 aa 300-600. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UBJ2
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500 - 1/3000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Associated Products
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Target data
Function
ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen (PubMed:21145416, PubMed:29397936). Like ABCD1 seems to have fatty acyl-CoA thioesterase (ACOT) and ATPase activities, according to this model, VLCFA-CoA as free VLCFA is transpoted in an ATP-dependent manner into peroxisomes after the hydrolysis of VLCFA-CoA mediated by the ACOT activity of ABCD2 (Probable) (PubMed:29397936). Shows overlapping substrate specificities with ABCD1 toward saturated fatty acids (FA) and monounsaturated FA (MUFA) but has a distinct substrate preference for shorter VLCFA (C22:0) and polyunsaturated fatty acid (PUFA) such as C22:6-CoA and C24:6-CoA (in vitro) (PubMed:21145416). Thus, may play a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:21145416).
Alternative names
ALD1, ALDL1, ALDR, ALDRP, ABCD2, ATP-binding cassette sub-family D member 2, Adrenoleukodystrophy-like 1, Adrenoleukodystrophy-related protein, hALDR
Recommended products
Rabbit Polyclonal ABCD2 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human ABCD2 aa 300-600.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human ABCD2 aa 300-600. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UBJ2
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Post translation modification - Glycoprotein
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The ABCD2 protein also known as ALDR (adrenoleukodystrophy-related protein) is a member of the ATP-binding cassette (ABC) transporter family located on the peroxisomal membrane. It plays a role in the transport of very-long-chain fatty acids (VLCFAs) into peroxisomes. The molecular mass of ABCD2 is approximately 80 kDa. Expression of ABCD2 occurs widely in tissues with high levels found in adrenal glands brain and liver.
- Biological function summary
ABCD2 influences the metabolism of lipids within cells by facilitating the import of VLCFAs which are subsequently broken down through beta-oxidation inside peroxisomes. It operates as part of a peroxisomal beta-oxidation complex. This protein also shares functional similarities with other ABC family transporters such as ABCD1 though with slightly different substrate specificities. Expression of ABCD2 increases in response to certain dietary and hormonal factors indicating a role in metabolic adaptation.
- Pathways
ABCD2 integrates into peroxisomal fatty acid beta-oxidation and lipid metabolism pathways. It associates closely with ABCD1 within these pathways contributing to the regulation of fatty acid levels in cells. A deficiency in ABCD2 affects these metabolic pathways by altering VLCFA transport and utilization leading to an imbalance with downstream metabolic effects. The protein also interacts with PPAR (peroxisome proliferator-activated receptors) signaling influencing lipid homeostasis.
- Associated diseases and disorders
Issues with ABCD2 are linked to adrenoleukodystrophy (ALD) an inherited disorder that affects the nervous system and adrenal glands due to the accumulation of VLCFAs. The disease connects ABCD2 and ABCD1 proteins since mutations in the ABCD1 gene are known to cause ALD. Researchers are interested in ABCD2's potential compensatory role in similar metabolic pathways possibly offering therapeutic implications. Recent studies also explore connections between ABCD2 dysregulation and liver disorders involving VLCFA metabolism but further research is necessary to establish these links conclusively.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-ABCD2 antibody (ab97383)
7.5% SDS PAGE
All lanes: Western blot - Anti-ABCD2 antibody (ab97383) at 1/1000 dilution
All lanes: A431 whole cell lysate at 30 µg
Predicted band size: 83 kDa
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