Anti-ABI2 antibody [EPR7069] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ABI2 also known as Abl-Interactor 2 is a protein encoded by the ABI2 gene. It has a molecular mass of approximately 53 kDa. ABI2 functions as a regulator of actin cytoskeleton dynamics and participates in processes involving cell motility and morphology. This protein is mainly expressed in neuronal tissues and is found in the cytoplasm suggesting its involvement in intracellular signaling pathways where actin rearrangement is important.

Biological function summary

ABI2 impacts cellular functions by interacting with the WAVE (WASP-family verprolin-homologous) complex. This interaction facilitates the regulation of actin polymerization important for processes such as cell migration and synaptic plasticity. ABI2 through the WAVE complex plays a role in the formation of lamellipodia cellular protrusions important for movement. This regulation ensures that cells respond effectively to external stimuli by reorganizing their cytoskeleton.

Pathways

The protein contributes significantly to the regulation of the Rac1 signaling pathway important for cytoskeletal remodeling. ABI2 works closely with proteins such as NCK proteins and phosphoinositides that are part of this pathway. Furthermore ABI2 interacts with the PAK family of kinases influencing downstream signaling that controls cell cycle progression and survival. ABI2’s role in these pathways highlights its importance in maintaining cellular architecture and dynamics.

Associated diseases and disorders

ABI2 is implicated in neurological conditions particularly Alzheimer's disease and schizophrenia. Its interaction with other proteins like APP (amyloid precursor protein) suggests a role in synaptic dysfunction seen in these disorders. ABI2’s involvement in actin dynamics connects it to synaptic defects that may contribute to cognitive impairments in Alzheimer's disease. Understanding ABI2’s function and interactions offers insights into therapeutic targets for these neurological conditions.