Rabbit Polyclonal ABI3 antibody. Suitable for IHC-P and reacts with Rat samples. Immunogen corresponding to Synthetic Peptide within Human ABI3 aa 100-200 conjugated to Keyhole Limpet Haemocyanin.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human ABI3 aa 100-200 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q9P2A4
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Predicted |
| Mouse | Predicted |
| Rat | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 1/100.00000 - 1/500.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Human | Dilution info - | Notes - |
Target data
Function
May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.
Alternative names
NESH, ABI3, ABI gene family member 3, New molecule including SH3, Nesh
Recommended products
Rabbit Polyclonal ABI3 antibody. Suitable for IHC-P and reacts with Rat samples. Immunogen corresponding to Synthetic Peptide within Human ABI3 aa 100-200 conjugated to Keyhole Limpet Haemocyanin.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human ABI3 aa 100-200 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q9P2A4
- Purification technique
- Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ABI3 also known as the ATP-binding cassette sub-family I member 3 is a protein involved in lipid transport and metabolism. It weighs approximately 34 kDa. This protein is expressed in various tissues most notably in the brain and immune cells. The presence of ABI3 has been noted in microglia which are the brain’s resident macrophages highlighting its significance in central nervous system functioning.
- Biological function summary
The protein ABI3 plays an essential role in phagocytic activity which helps in clearing cellular debris and toxins supporting immune response and maintenance of tissue homeostasis. ABI3 integrates into a larger macromolecular complex where it interacts with other proteins to influence phagocytosis efficiency. Such interactions empower ABI3 to modulate inflammatory responses thereby contributing to cellular defense mechanisms.
- Pathways
Different cellular processes involve ABI3 especially the PI3K-Akt pathway and the immune response pathways. The PI3K-Akt pathway is critical for cell survival and growth where ABI3 modulates these activities. ABI3 interacts with other proteins in this pathway like AKT1 to impact cellular metabolism and survival decisions. Furthermore its involvement in immune response pathways highlights its role in maintaining cellular health through modulating both inflammation and phagocytosis.
- Associated diseases and disorders
ABI3 has associations with neurodegenerative diseases such as Alzheimer's disease and frontotemporal dementia. Its role in affected microglial function directly links to inflammatory processes observed in these conditions. Additionally ABI3 interacts with proteins like TREM2 in microglial cells which research connects to Alzheimer’s disease offering insights into potential therapeutic targets.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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Full details and terms and conditions can be found here:
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABI3 antibody (ab214318)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat kidney tissue labeling with ABI3 with ab214318 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.
Downloads
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- Visit the general protocols
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