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Rabbit Polyclonal ABIN3 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human TNIP3 conjugated to Keyhole Limpet Haemocyanin.

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Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 99% PBS

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Synthetic Peptide within Human TNIP3 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q96KP6
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Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-P
Human
Tested
Tested
Mouse
Predicted
Predicted

Tested
Tested

Species

Human

Dilution info

1.00000-2.00000 µg/mL

Notes

-

Predicted
Predicted

Species

Mouse

Dilution info

-

Notes

-

Tested
Tested

Species

Human

Dilution info

5 µg/mL

Notes

-

Predicted
Predicted

Species

Mouse

Dilution info

-

Notes

-

Target data

Function

Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.

Alternative names

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Rabbit Polyclonal ABIN3 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human TNIP3 conjugated to Keyhole Limpet Haemocyanin.

Alternative names

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen

Synthetic Peptide within Human TNIP3 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Database link Q96KP6

Purification technique

Affinity purification Immunogen

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

Biological summary

ABIN3 regulates immune response and participates in controlling inflammation. It acts together with other components to form signaling complexes. This complex assembly plays a role in dampening excessive inflammatory signals. By regulating components of innate immune responses ABIN3 helps maintain immune homeostasis. Its interaction is significant in controlling the overall activity within signaling hubs that manage inflammation.

Mechanical summary

ABIN3 also known as TNIP3 is a protein with a molecular mass of approximately 68 kDa. It is widely expressed in various tissues notably in the immune system. ABIN3 acts as an important mediator in modulating cellular responses to external stress signals. It interacts with several signaling pathways modulating functions at the cellular level. ABIN3's action significantly regulates immune responses by binding to and inhibiting specific proteins involved in inflammation.

Pathway

ABIN3 involves itself in critical inflammatory pathways such as the NF-κB pathway. This protein modulates NF-κB activation by hindering its activity ensuring proper balance in immune signaling. ABIN3 connects with proteins like A20 acting together to prevent overactivation that could lead to inflammation. Such modulation is central in managing cellular defenses and preventing inappropriate tissue damage.

Disease

Researchers link ABIN3 to conditions like inflammatory bowel disease (IBD) and rheumatoid arthritis. In these diseases ABIN3's role in moderating immune response becomes relevant as dysfunctions here can lead to excessive inflammation. ABIN3 works in concert with proteins like TNFα where an imbalance may result in chronic inflammatory states characteristic of these diseases. Understanding these interactions offers potential therapeutic avenues in treating inflammatory disorders.

Product promise

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2 product images

  • Western blot - Anti-ABIN3 antibody (ab113748), expandable thumbnail

    Western blot - Anti-ABIN3 antibody (ab113748)

    All lanes: Western blot - Anti-ABIN3 antibody (AB113748) at 1 µg/mL

    All lanes: Human spleen tissue lysate

    Predicted band size: 39 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABIN3 antibody (ab113748), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABIN3 antibody (ab113748)

    ab113748, at 5 µg/ml, staining ABIN3 in formalin fixed, paraffin embedded, Human adrenal tissue by Immunohistochemistry

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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