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AB113748

Anti-ABIN3 antibody

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(3 Publications)

Rabbit Polyclonal ABIN3 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human TNIP3 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

ABIN3, LIND, TNIP3, TNFAIP3-interacting protein 3, A20-binding inhibitor of NF-kappa-B activation 3, Listeria-induced gene protein, ABIN-3

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABIN3 antibody (AB113748)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABIN3 antibody (AB113748)

ab113748, at 5 µg/ml, staining ABIN3 in formalin fixed, paraffin embedded, Human adrenal tissue by Immunohistochemistry

Western blot - Anti-ABIN3 antibody (AB113748)
  • WB

Unknown

Western blot - Anti-ABIN3 antibody (AB113748)

All lanes:

Western blot - Anti-ABIN3 antibody (ab113748) at 1 µg/mL

Lane 1:

Human spleen tissue lysate

Lane 2:

Human spleen tissue lysate with blocking peptide

Predicted band size: 39 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human TNIP3 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q96KP6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ABIN3 also known as TNIP3 is a protein with a molecular mass of approximately 68 kDa. It is widely expressed in various tissues notably in the immune system. ABIN3 acts as an important mediator in modulating cellular responses to external stress signals. It interacts with several signaling pathways modulating functions at the cellular level. ABIN3's action significantly regulates immune responses by binding to and inhibiting specific proteins involved in inflammation.
Biological function summary

ABIN3 regulates immune response and participates in controlling inflammation. It acts together with other components to form signaling complexes. This complex assembly plays a role in dampening excessive inflammatory signals. By regulating components of innate immune responses ABIN3 helps maintain immune homeostasis. Its interaction is significant in controlling the overall activity within signaling hubs that manage inflammation.

Pathways

ABIN3 involves itself in critical inflammatory pathways such as the NF-κB pathway. This protein modulates NF-κB activation by hindering its activity ensuring proper balance in immune signaling. ABIN3 connects with proteins like A20 acting together to prevent overactivation that could lead to inflammation. Such modulation is central in managing cellular defenses and preventing inappropriate tissue damage.

Researchers link ABIN3 to conditions like inflammatory bowel disease (IBD) and rheumatoid arthritis. In these diseases ABIN3's role in moderating immune response becomes relevant as dysfunctions here can lead to excessive inflammation. ABIN3 works in concert with proteins like TNFα where an imbalance may result in chronic inflammatory states characteristic of these diseases. Understanding these interactions offers potential therapeutic avenues in treating inflammatory disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.
See full target information TNIP3
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cancer cell international 23:49 PubMed36932402

2023

Changes in calpain-2 expression during glioblastoma progression predisposes tumor cells to temozolomide resistance by minimizing DNA damage and p53-dependent apoptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Maren Nicole Stillger,Chia-Yi Chen,Zon Weng Lai,Mujia Li,Agnes Schäfer,Axel Pagenstecher,Christopher Nimsky,Jörg Walter Bartsch,Oliver Schilling

Oxidative medicine and cellular longevity 2022:5210870 PubMed35368864

2022

The Imbalance of Mitochondrial Homeostasis of Peripheral Blood-Derived Macrophages Mediated by MAFLD May Impair the Walking Ability of Elderly Patients with Osteopenia.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaojun Wang,Xuanqi Liu,Peqing He,Kangwei Guan,Yijing Yang,Yiming Lei,Jianhua Cai,Wenhao Wang,Tao Wu

Cell metabolism 31:726-740.e8 PubMed32268115

2020

TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation.

Applications

Unspecified application

Species

Unspecified reactive species

Dan Liu,Peng Zhang,Junjie Zhou,Rufang Liao,Yan Che,Mao-Mao Gao,Jiaqi Sun,Jingjing Cai,Xu Cheng,Yongping Huang,Guopeng Chen,Hongyu Nie,Yan-Xiao Ji,Xiao-Jing Zhang,Zan Huang,Haibo Xu,Zhi-Gang She,Hongliang Li
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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