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AB67721

Anti-ABLIM3 antibody

4

(1 Review)

|

(2 Publications)

Mouse Polyclonal ABLIM3 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ABLIM3.

View Alternative Names

KIAA0843, HMFN1661, ABLIM3, Actin-binding LIM protein 3, abLIM-3, Actin-binding LIM protein family member 3

1 Images
Western blot - Anti-ABLIM3 antibody (AB67721)
  • WB

Unknown

Western blot - Anti-ABLIM3 antibody (AB67721)

All lanes:

Western blot - Anti-ABLIM3 antibody (ab67721) at 1/500 dilution

Lane 1:

ABLIM3 transfected 293T cell lysate at 25 µg

Lane 2:

Non transfected 293T cell lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP conjugated at 1/2500 dilution

Predicted band size: 78 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human ABLIM3.

O94929

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ABLIM3 short for Actin Binding LIM protein 3 is a target with a mass of approximately 75 kDa. This protein contains several LIM domains and primarily binds with actin filaments. It functions as an adaptor facilitating cytoskeletal dynamics and signal transmissions. You find ABLIM3 expressed in various tissues including central nervous tissue and muscles which indicates its broad role in maintaining cellular framework and functions.
Biological function summary

ABLIM3 plays a critical role in cell shape and motility by connecting actin filaments with signal transduction pathways. This protein associates with the cytoskeleton and influences changes in actin organization. It often works as part of a protein complex that includes LIM domain proteins which modulate actin cytoskeleton stability and cell signaling. These interactions highlight its importance in controlling cellular responses to extracellular signals.

Pathways

ABLIM3 is integral to pathways related to cell motility and cytoskeletal organization. It contributes to the arrangement of actin filaments affecting cell migration and adhesion processes. In particular ABLIM3 interacts with proteins like integrins and vinculin in these pathways coordinating changes necessary for cellular movement and structure. These associations support cellular architecture and movement adaptations.

Abnormal expressions of ABLIM3 relate to certain cancers and neurological disorders. In cancer especially in metastatic diseases disruptions in ABLIM3-mediated signaling can lead to altered cell motility promoting tumor growth and spread. For neurological disorders ABLIM3 connections with proteins such as actin-related proteins may contribute to pathologies involving synaptic stability and neurodegeneration. These links illustrate the significant impact of ABLIM3 in health and disease contexts.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.
See full target information ABLIM3
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Neuron 111:3084-3101.e5 PubMed37797581

2023

An inhibitory circuit-based enhancer of DYRK1A function reverses Dyrk1a-associated impairment in social recognition.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Tzu Shih,Jason Bondoc Alipio,Amar Sahay

Nature medicine 24:438-449 PubMed29529016

2018

Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization.

Applications

Unspecified application

Species

Unspecified reactive species

Nannan Guo,Marta E Soden,Charlotte Herber,Michael TaeWoo Kim,Antoine Besnard,Paoyan Lin,Xiang Ma,Constance L Cepko,Larry S Zweifel,Amar Sahay
View all publications
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Product promise

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