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AB33404

Anti-ABO antibody [BRIC231]

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(3 Publications )

Mouse Monoclonal ABO antibody. Suitable for Flow Cyt, Agg and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Cell preparation containing Histo-blood group ABO system transferase protein.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

BRIC231

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

Flow Cyt, Agg

applications

Immunogen

Cell preparation containing Histo-blood group ABO system transferase protein. The exact immunogen used to generate this antibody is proprietary information.

P16442

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "Agg" : {"fullname" : "Agglutination", "shortname":"Agg"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>", "Agg-species-checked": "guaranteed", "Agg-species-dilution-info": "", "Agg-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffer
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The ABO blood group system frequently referred to as ABO is a critical component in determining blood type. It involves the presence of antigens on the surface of red blood cells which are glycosyltransferase enzymes that transfer sugar residues onto the H antigen. The gene responsible for this system is located on chromosome 9 and the variations in the gene produce the A B and O blood types. These glycoproteins and glycolipids confer blood group specificity. ABO is found in the erythrocytic lineage and is an integral part of the blood plasma context.
Biological function summary

The ABO proteins modulate immune response mechanisms. They participate in the formation of specific antigens and antibodies that define the ABO blood group system. These proteins are not part of a larger complex but interact closely with components in the immune system. In individuals the presence or absence of antigen types influences immune activity and the antigen-antibody structure is essential in transfusion medicine.

Pathways

Researchers link the ABO system with several immune response pathways. The system integrates into the complement system and humoral immunity affecting compatibility in blood transfusions. It is indirectly related to proteins in the complement cascade and these interactions facilitate or hinder immune reactions during transfusions and organ transplants. The pathway involvement highlights the system’s significance in cellular communication and immune mobilization.

ABO incompatibility can lead to hemolytic disease of the newborn and transfusion reactions. In such contexts the presence of incompatible ABO antigens triggers immune responses resulting in adverse events. It also indirectly connects to diseases like gastric cancer where blood type prevalence indicates varying disease risk profiles. The interaction with proteins such as the Rh factor can exacerbate these conditions showing how ABO status affects susceptibility and symptom severity.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens : A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of N-acetyl-alpha-D-galactosamine (GalNAc)) or to the B antigen (by addition of galactose (Gal)), whereas O individuals lack such activity and express the H antigen precursor unmodified.. Catalyzes the transfer of GalNAc or Gal in an alpha1,3 linkage to the terminal Gal of all five types of naturally occurring H antigens, forming the antigenic structures of the A and B blood groups.
See full target information Histo-blood group ABO system transferase

Alternative Names

Histo-blood group ABO system transferase, Fucosylglycoprotein 3-alpha-galactosyltransferase, Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase, Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase, Glycoprotein-fucosylgalactoside alpha-galactosyltransferase, Histo-blood group A transferase, Histo-blood group B transferase, NAGAT, A transferase, GTA, B transferase, GTB, ABO
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Publications (3)

Recent publications for all applications. Explore the full listand refine your search

Methods in molecular biology (Clifton, N.J.) 2460:33-44 PubMed34972929

2022

Multiplex Glycan Bead Array (MGBA ) for High Throughput and High Content Analyses of Glycan-Binding Proteins Including Natural Anti-Glycan Antibodies.

Applications

Unspecified application

Species

Unspecified reactive species

Sharad Purohit,Jin-Xiong She

Nature communications 9:258 PubMed29343722

2018

Multiplex glycan bead array for high throughput and high content analyses of glycan binding proteins.

Applications

Unspecified application

Species

Unspecified reactive species

Sharad Purohit,Tiehai Li,Wanyi Guan,Xuezheng Song,Jing Song,Yanna Tian,Lei Li,Ashok Sharma,Boying Dun,David Mysona,Sharad Ghamande,Bunja Rungruang,Richard D Cummings,Peng George Wang,Jin-Xiong She

The Journal of biological chemistry 289:16462-77 PubMed24753245

2014

Carbohydrate sequence of the prostate cancer-associated antigen F77 assigned by a mucin O-glycome designer array.

Applications

Unspecified application

Species

Unspecified reactive species

Chao Gao,Yan Liu,Hongtao Zhang,Yibing Zhang,Michiko N Fukuda,Angelina S Palma,Radoslaw P Kozak,Robert A Childs,Motohiro Nonaka,Zhen Li,Don L Siegel,Peter Hanfland,Donna M Peehl,Wengang Chai,Mark I Greene,Ten Feizi
View all publications
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Product promise

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