Anti-ACAP1 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ACAP1 also known as ADP-ribosylation factor GTPase-activating protein 1 weighs around 81 kDa. This protein functions as a GTPase-activating protein and plays a significant role in intracellular trafficking and cargo sorting. ACAP1 is expressed in various tissues including lungs and kidneys and typically resides in the cytoplasm and associated vesicular membranes. Its precise role in cellular transport mechanisms lies in its ability to regulate the activity of the ARF family of small GTPases which are pivotal to vesicle budding and trafficking.

Biological function summary

ACAP1 engages in both cellular membrane dynamics and actin cytoskeleton organization. It forms part of a multiprotein complex interacting with molecules like clathrin and cargo adaptors to mediate endocytosis and recycling pathways. In addition to its involvement in vesicular transport ACAP1 participates in actin-driven changes in membrane structure necessary for effective cargo handling and cellular response to extracellular signals. This dual functionality emphasizes its important role in maintaining cellular homeostasis.

Pathways

ACAP1 involvement extends to the Arf6 signaling pathway and the endocytic recycling pathway. These pathways highlight its function in cellular internalization and receptor recycling. ACAP1 interacts with proteins such as GRK2 and AP-2 in these pathways facilitating the orchestrated regulation of cargo uptake and recycling at the plasma membrane. Moreover its actions influence intracellular signal transduction processes showcasing its importance in maintaining cellular communication and environmental interaction.

Associated diseases and disorders

ACAP1 associates with conditions such as cancer and type 2 diabetes. In cancer dysregulation of ACAP1 can lead to aberrant cellular growth and migration due to its role in cell surface receptor recycling and turnover. Abnormalities in ACAP1 function also relate to diabetes as impaired endocytosis and insulin receptor recycling can affect glucose homeostasis. Further connection to these diseases occurs via interactions with proteins like Rab11 and Eps15 indicating that ACAP1 impacts pathophysiological pathways and represents a potential target for therapeutic intervention.