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AB220740

Anti-ACD antibody

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(2 Publications)

Rabbit Polyclonal ACD antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ACD aa 250-400.

View Alternative Names

PIP1, PTOP, TINT1, TPP1, ACD, Adrenocortical dysplasia protein homolog, POT1 and TIN2-interacting protein

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-ACD antibody (AB220740)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-ACD antibody (AB220740)

Immunofluorescent analysis of PFA-fixed/Triton X-100 permeabilized U-2 OS cells labeling ACD with ab220740 at 4 μg/ml (green).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human ACD aa 250-400. The exact immunogen used to generate this antibody is proprietary information.

Q96AP0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The target ACD also known as TPP1 is a component of the shelterin complex which protects telomeres. Its molecular mass is approximately 55 kDa. ACD is expressed mainly in the nucleus of cells where it interacts with telomeric DNA. ACD plays a role in regulating telomere length and stability contributing to cellular replication and aging processes.
Biological function summary

ACD interacts with other proteins within the shelterin complex such as POT1 and TRF1. This complex is critical in protecting chromosome ends from DNA damage responses. ACD is important for maintaining telomere integrity supporting cellular proliferation. When ACD functions properly it helps prevent chromosomal instability and potential oncogenic transformations.

Pathways

ACD participates in the telomere maintenance pathway and the DNA damage response pathway. ACD closely associates with proteins like POT1 and TRF2 in these pathways. Through these interactions ACD assists in modulating telomerase activity which is essential for balancing telomere elongation and degradation.

Disruptions in ACD function have links to conditions like dyskeratosis congenita and some cancers. ACD malfunction contributes to telomere shortening leading to premature aging and increased cancer risk. It associates with proteins like TERT in these contexts where imbalances can exacerbate disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.
See full target information ACD
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:2135 PubMed40032835

2025

Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites.

Applications

Unspecified application

Species

Unspecified reactive species

Ayenachew Bezawork-Geleta,Camille J Devereux,Stacey N Keenan,Jieqiong Lou,Ellie Cho,Shuai Nie,David P De Souza,Vinod K Narayana,Nicole A Siddall,Carlos H M Rodrigues,Stephanie Portelli,Tenghao Zheng,Hieu T Nim,Mirana Ramialison,Gary R Hime,Garron T Dodd,Elizabeth Hinde,David B Ascher,David A Stroud,Matthew J Watt

International journal of molecular sciences 22: PubMed33673424

2021

A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres.

Applications

Unspecified application

Species

Unspecified reactive species

Elisa Mentegari,Federica Bertoletti,Miroslava Kissova,Elisa Zucca,Silvia Galli,Giulia Tagliavini,Anna Garbelli,Antonio Maffia,Silvia Bione,Elena Ferrari,Fabrizio d'Adda di Fagagna,Sofia Francia,Simone Sabbioneda,Liuh-Yow Chen,Joachim Lingner,Valerie Bergoglio,Jean-Sébastien Hoffmann,Ulrich Hübscher,Emmanuele Crespan,Giovanni Maga
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Product promise

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