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AB192390

Anti-ACG antibody

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(1 Publication)

Rabbit Polyclonal ACG antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human DOCK11 aa 550-650.

View Alternative Names

ZIZ2, DOCK11, Dedicator of cytokinesis protein 11, Activated Cdc42-associated guanine nucleotide exchange factor, Zizimin-2, ACG

1 Images
Western blot - Anti-ACG antibody (AB192390)
  • WB

Supplier Data

Western blot - Anti-ACG antibody (AB192390)

All lanes:

Western blot - Anti-ACG antibody (ab192390)

Lane 1:

HeLa whole cell lysate

Lane 2:

Raw264.7 whole cell lysate

Lane 3:

PC12 whole cell lysate

Predicted band size: 238 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human DOCK11 aa 550-650. The exact immunogen used to generate this antibody is proprietary information.

Q5JSL3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab192390 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein target ACG also known as Acetyl-CoA synthetase is an essential enzyme that plays a significant role in cellular metabolism. This enzyme catalyzes the conversion of acetate into acetyl-CoA a critical step in lipid synthesis and energy production. ACG exhibits a molecular mass of approximately 75 kDa. The protein expresses in tissues such as the liver and adipose tissue where high metabolic activity requires efficient lipid and energy metabolism.
Biological function summary

ACG facilitates the activation of acetate molecules into acetyl-CoA integrating into broader metabolic processes and contributing to lipid biosynthesis and energy production. The enzyme is not known to be a part of any large complex yet its function is critical in linking acetyl-CoA to numerous biochemical pathways. The ACG protein also assists in converting excess carbohydrates into fatty acids emphasizing its role in energy homeostasis.

Pathways

The activity of ACG is integrated into both the tricarboxylic acid (TCA) cycle and the pathway for fatty acid biosynthesis. In the TCA cycle acetyl-CoA enters to generate energy through oxidative phosphorylation. In fatty acid biosynthesis acetyl-CoA serves as a substrate for engineering long-chain fatty acids. Related proteins such as citrate synthase and fatty acid synthase associate indirectly with ACG through these pathways forming important links in the metabolic network.

Defects in ACG can relate to metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). In metabolic syndrome impaired ACG function disrupts lipid metabolism which can lead to obesity and insulin resistance. In NAFLD excess accumulation of lipids in the liver involves altered ACG activity affecting liver function. Proteins such as AMP-activated protein kinase (AMPK) are associated with ACG in these disorders through their regulation of metabolic pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed : 37342957). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (By similarity). Facilitates filopodia formation through the activation of CDC42 (PubMed : 37342957).
See full target information DOCK11
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of cachexia, sarcopenia and muscle 16:e70002 PubMed40745399

2025

Exogenous Nucleotides Supplementation Attenuates Age-Related Sarcopenia.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Wu,Rui Liu,Na Zhu,Xiujuan Wang,Chan Wei,Xiaoyang An,Meihong Xu,Yong Li
View all publications
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