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AB237522

Anti-ACMSD antibody

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(1 Publication)

Rabbit Polyclonal ACMSD antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase aa 1-150.

View Alternative Names

2-amino-3-carboxymuconate-6-semialdehyde decarboxylase, Picolinate carboxylase, ACMSD

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-ACMSD antibody (AB237522)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-ACMSD antibody (AB237522)

HepG2 (human liver hepatocellular carcinoma cell line) cells stained for ACMSD (green) using ab237522 at 1/100 dilution in ICC/IF. Secondary antibody is Alexa Fluor® 488-congugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ACMSD antibody (AB237522)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ACMSD antibody (AB237522)

Paraffin-embedded human kidney tissue stained for ACMSD using ab237522 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ACMSD antibody (AB237522)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ACMSD antibody (AB237522)

Paraffin-embedded human liver cancer tissue stained for ACMSD using ab237522 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q8TDX5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity greater than 95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ACMSD also known as 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase is an enzyme with a mass of around 39 kDa. It plays an important role in the metabolism of tryptophan converting 2-amino-3-carboxymuconate-6-semialdehyde into alpha-amino-beta-carboxymuconate-epsilon-semialdehyde. ACMSD is expressed mostly in the liver and kidney tissues. It functions at a critical step in the kynurenine pathway which processes tryptophan into several metabolites.
Biological function summary

ACMSD regulates the flux of metabolites through the kynurenine pathway influencing the production of NAD+ and quinolinic acid. ACMSD converts intermediates in the pathway which prevents the excessive build-up of quinolinic acid a neurotoxin. ACMSD is not typically part of a larger enzyme complex but interacts functionally within the pathway components. Its expression and activity impact the levels of various metabolites affecting cellular functions and energy metabolism.

Pathways

The kynurenine pathway is where ACMSD fits significantly. In this pathway ACMSD influences the synthesis of NAD+ which is essential for energy production and cellular signaling. ACMSD links closely with other enzymes like kynurenine 3-monooxygenase and kynureninase. By controlling the balance between different metabolites ACMSD helps maintain homeostasis and prevents potential toxic effects from accumulated intermediates like quinolinic acid.

ACMSD attracts attention for its association with neurological conditions and inflammatory diseases. Disruptions in its functioning can lead to abnormal levels of quinolinic acid contributing to neurodegenerative diseases like Alzheimer's and multiple sclerosis. Additionally abnormal regulation of ACMSD can affect tryptophan metabolism impacting disorders like chronic kidney disease. Connections with proteins like indoleamine 23-dioxygenase provide a broader understanding of its role in disease contexts.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
See full target information 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncology reports 51: PubMed38624012

2024

Abscisic acid signaling through LANCL2 and PPARγ induces activation of p38MAPK resulting in dormancy of prostate cancer metastatic cells.

Applications

Unspecified application

Species

Unspecified reactive species

Keshab Raj Parajuli,Younghun Jung,Russell S Taichman
View all publications
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Product promise

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