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Rabbit Polyclonal ACOT7 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human Cytosolic acyl coenzyme A thioester hydrolase.

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Images

Western blot - Anti-ACOT7 antibody (AB85151), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ACOT7 antibody (AB85151), expandable thumbnail

Publications

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

Preservative: 0.02% Sodium azide
Constituents: 2% BSA

Form

Lyophilized

Clonality

Polyclonal

Immunogen

  • Synthetic Peptide within Human Cytosolic acyl coenzyme A thioester hydrolase. The exact immunogen used to generate this antibody is proprietary information. Database link O00154

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-P
Human
Tested
Tested
Mouse
Predicted
Predicted
Rat
Predicted
Predicted

Tested
Tested

Species

Human

Dilution info

1/200 - 1/1000

Notes

-

Predicted
Predicted

Species

Mouse, Rat

Dilution info

-

Notes

-

Tested
Tested

Species

Human

Dilution info

1/50 - 1/200

Notes

-

Predicted
Predicted

Species

Mouse, Rat

Dilution info

-

Notes

-

Associated Products

Select an associated product type

1 product for Alternative Product

Target data

Function

Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:10578051). Preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (PubMed:10578051). May play an important physiological function in brain (PubMed:10578051).

Alternative names

Recommended products

Rabbit Polyclonal ACOT7 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human Cytosolic acyl coenzyme A thioester hydrolase.

Key facts

Isotype

IgG

Form

Lyophilized

Clonality

Polyclonal

Immunogen
  • Synthetic Peptide within Human Cytosolic acyl coenzyme A thioester hydrolase. The exact immunogen used to generate this antibody is proprietary information. Database link O00154
Purification technique

Affinity purification Immunogen

Reconstitution

reconstitute with water at 200µL

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ACOT7 also known as cytosolic acyl-CoA thioesterase 7 plays an important role in lipid metabolism by hydrolyzing acyl-CoA thioesters into free fatty acids and CoA. This enzyme possesses a molecular mass of approximately 44 kilodaltons. ACOT7 primarily expresses in the brain with significant levels in neurons. This distribution suggests involvement in processes related to brain lipid metabolism and energy homeostasis.

Biological function summary

ACOT7 influences the regulation of lipid pools and fatty acid signaling in neural cells. It participates in the modulation of free fatty acid concentrations affecting energy metabolism and neuronal function. While ACOT7 does not typically associate with larger protein complexes its enzymatic action impacts the availability and signaling of lipid molecules within the cell potentially influencing cellular responses and energy dynamics.

Pathways

ACOT7 plays a role in fatty acid metabolism and energy homeostasis pathways. It connects with lipid metabolism processes involving enzymes like fatty acid synthase and acyl-CoA synthetase enzymes. By modulating the levels of acyl-CoA and free fatty acids ACOT7 affects broader metabolic pathways that control cellular energy balance and lipid synthesis in brain tissues.

Associated diseases and disorders

ACOT7 links to neurological conditions and energy metabolism disorders. Its alteration associates with neurodegenerative diseases such as Alzheimer's disease due to its role in maintaining neuronal lipid balance. Furthermore conditions like metabolic syndrome may relate to changes in ACOT7 function given its impact on lipid metabolism. Proteins like amyloid-beta precursor protein in Alzheimer's disease have connections to ACOT7 through these metabolic processes.

Product promise

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2 product images

  • Western blot - Anti-ACOT7 antibody (ab85151), expandable thumbnail

    Western blot - Anti-ACOT7 antibody (ab85151)

    All lanes: Western blot - Anti-ACOT7 antibody (ab85151) at 1/500 dilution

    All lanes: human fetal brain lysate

    Predicted band size: 42 kDa

    Observed band size: 42 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ACOT7 antibody (ab85151), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ACOT7 antibody (ab85151)

    ab85151, at a 1/100 dilution, staining ACOT7 in formalin fixed, paraffin embedded human brain tissue by Immunohistochemistry.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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