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AB197808

Anti-ACOX2 antibody

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(3 Publications)

Rabbit Polyclonal ACOX2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Fusion protein corresponding to Peroxisomal acyl-coenzyme A oxidase 2, fused to Peroxisomal acyl-coenzyme A oxidase 2.

View Alternative Names

Peroxisomal acyl-coenzyme A oxidase 2, Trihydroxycoprostanoyl-CoA oxidase, THCA-CoA oxidase, THCCox, ACOX2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ACOX2 antibody (AB197808)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ACOX2 antibody (AB197808)

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling ACOX2 using ab197808 at 1/20 dilution.

Western blot - Anti-ACOX2 antibody (AB197808)
  • WB

Supplier Data

Western blot - Anti-ACOX2 antibody (AB197808)

Gel : 8%SDS-PAGE

All lanes:

Western blot - Anti-ACOX2 antibody (ab197808) at 1/350 dilution

Lane 1:

Mouse liver lysates at 40 µg

Lane 2:

Mouse kidney lysates at 40 µg

Predicted band size: 77 kDa

false

Exposure time: 2min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Fusion protein corresponding to Peroxisomal acyl-coenzyme A oxidase 2, fused to Peroxisomal acyl-coenzyme A oxidase 2. The exact immunogen used to generate this antibody is proprietary information.

Q99424

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ACOX2 also known as acyl-CoA oxidase 2 or branched-chain acyl-CoA oxidase plays an important role in fatty acid metabolism. This enzyme weighs about 75 kDa and resides in the peroxisomes. It catalyzes the initial step in the peroxisomal beta-oxidation pathway of branched-chain fatty acids. ACOX2 expression can be detected in various tissues including the liver and kidneys where its metabolic functions are essential.
Biological function summary

The ACOX2 protein is responsible for the oxidation of long and very-long-chain fatty acids. Its activity serves as the first step in their catabolism contributing to lipid homeostasis. While ACOX2 functions as a monomer it operates in conjunction with other enzymes facilitating the breakdown of branched-chain fatty acids into simpler molecules for energy production and management of lipid derivatives within the body.

Pathways

ACOX2 functions in the peroxisomal beta-oxidation pathway and fatty acid degradation pathway. These pathways oversee the breakdown of branched-chain fatty acids and other non-standard fatty acids. ACOX2's activity relates to other proteins like ACOX1 and peroxisomal enzyme complexes which carry out subsequent steps in fatty acid oxidation. Through these pathways ACOX2 maintains energy balance and lipid regulation at the cellular level.

ACOX2 has been linked to metabolic disorders and peroxisomal biogenesis defects such as Zellweger syndrome. Mutations or deficiencies in ACOX2 can result in the buildup of branched-chain fatty acids leading to metabolic disruptions. Additionally disorders like X-linked adrenoleukodystrophy may involve related enzymes such as ACOX1 which share similar pathways and contribute to the disease etiology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids (PubMed : 27884763). Capable of oxidizing short as well as long chain 2-methyl branched fatty acids (By similarity).
See full target information Peroxisomal acyl-coenzyme A oxidase 2
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cell proliferation 58:e13755 PubMed39329203

2024

Dynamic transcriptomic and regulatory networks underpinning the transition from fetal primordial germ cells to spermatogonia in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jiexiang Zhao,Kang Tang,Gurong Jiang,Xinyan Yang,Manman Cui,Cong Wan,Zhaoxiang Ouyang,Yi Zheng,Zhaoting Liu,Mei Wang,Xiao-Yang Zhao,Gang Chang

Experimental and therapeutic medicine 28:361 PubMed39071912

2024

Sodium sulphate ameliorates hypercholesterolemia via the upregulation of in hepatocytes and alleviates hepatic insulin resistance via the downregulation of in mice with high cholesterol diets.

Applications

Unspecified application

Species

Unspecified reactive species

Yanhong Yang,Siping Yu,Hedong Rong,Zili Lei,Changyuan Yang,Huijuan Wu,Tianle Zhang,Fei Yang,Ya Nie,Lei Chen,Qing Hu,Qi Song,Jiao Guo

Food & nutrition research 67: PubMed36794015

2023

The PPARα/CYP4A14 bile acid pathway is associated with lipid metabolism disorders caused by low birth weight with high-fat diet.

Applications

Unspecified application

Species

Unspecified reactive species

Fei Zhou,Linquan Yang,Wenwen Sun,Xing Wang,Na Guo,Huijuan Ma,Linlin Yang
View all publications
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