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AB191075

Anti-ACRV1 antibody [EPR15667(B)] - C-terminal

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(1 Publication)

Rabbit Recombinant Monoclonal ACRV1 antibody. C-terminal. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

Acrosomal protein SP-10, Acrosomal vesicle protein 1, ACRV1

1 Images
Western blot - Anti-ACRV1 antibody [EPR15667(B)] - C-terminal (AB191075)
  • WB

Supplier Data

Western blot - Anti-ACRV1 antibody [EPR15667(B)] - C-terminal (AB191075)

Intra Acrosomal Protein could be glycosylated, which could cause higher MW than the predicted one

All lanes:

Western blot - Anti-ACRV1 antibody [EPR15667(B)] - C-terminal (ab191075) at 1/10000 dilution

All lanes:

Human testis lysate at 20 µg

Secondary

All lanes:

Anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1000 dilution

Predicted band size: 28 kDa

Observed band size: 14-36 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR15667(B)

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

Based on the sequence analysis, ab191075 recognizes 10 isoforms with the predicted MWs of 14 - 28KDa.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ACRV1 also known as acidic epididymal glycoprotein (AEG) is a protein that plays a role in reproductive biology. This protein has a molecular mass of approximately 24 kDa. Expression of ACRV1 mainly occurs in the testis more specifically in germ cells during spermatogenesis. Due to its specialized expression ACRV1 serves functions related to sperm development and maturation.
Biological function summary

Acidic epididymal glycoprotein (AEG) contributes to the stability and function of the acrosome a cap-like structure in sperm cells necessary for fertilization. ACRV1 is part of a larger protein complex involved in this process ensuring structural integrity and facilitating sperm-egg interaction. The acrosome plays a critical role in releasing enzymes that allow sperm to penetrate the egg’s outer layer enabling fertilization.

Pathways

Sperm maturation and fertilization processes rely on the presence of ACRV1. This protein is involved in the spermatogenesis pathway which is essential for producing functional and viable sperm. ACRV1 interacts with alpha-lactalbumin and protamines during this pathway to maintain chromatin stability and enable appropriate sperm head structure changes important for successful fertilization.

Abnormalities in ACRV1 expression or function can affect male fertility potentially leading to infertility conditions such as azoospermia. Defects in ACRV1 can disrupt normal sperm development contributing to issues with acrosome formation. ACRV1 is associated with other sperm-specific proteins like protamine 1 and cathepsin L which are implicated in compromised spermatozoa function and male reproductive disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Acrosomal protein SP-10
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 44:115169 PubMed39792555

2025

Conserved patterns of transcriptional dysregulation, heterogeneity, and cell states in clear cell kidney cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Olivia Lombardi,Ran Li,Faiz Jabbar,Hannah Evans,Silvia Halim,Joanna D C C Lima,Lisa Browning,Helen M Byrne,Hani Choudhry,Peter J Ratcliffe,David R Mole
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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