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AB73352

Anti-ACSF3 antibody

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(1 Publication)

Mouse Polyclonal ACSF3 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ACSF3.

View Alternative Names

PSEC0197, ACSF3, Acyl-CoA synthetase family member 3

1 Images
Western blot - Anti-ACSF3 antibody (AB73352)
  • WB

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Western blot - Anti-ACSF3 antibody (AB73352)

All lanes:

Western blot - Anti-ACSF3 antibody (ab73352) at 5 µg/mL

Lane 1:

ACSF3 transfected 293T cell lysate at 25 µg

Lane 2:

Non transfected cell lysate at 25 µg

Secondary

All lanes:

goat anti-mouse (H&L)-HRP conjugate at 1/2500 dilution

Predicted band size: 64 kDa

Observed band size: 64 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human ACSF3.

Q4G176

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-5 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ACSF3 also known as acyl-CoA synthetase family member 3 is involved in converting free fatty acids into fatty acyl-CoA esters which are necessary for various metabolic processes. The ACSF3 protein has a molecular mass of approximately 64 kDa and is expressed in mitochondria within cells. It plays a particularly important role in the liver where it assists in lipid metabolism and energy production. The presence of this protein is important for cells that require efficient fatty acid processing.
Biological function summary

This protein contributes to cellular energy homeostasis and lipid biosynthesis. ACSF3 is not part of a known protein complex. However it functions effectively in the mitochondrial environment where it integrates with other metabolic processes. This protein is involved in the generation of substrates for the tricarboxylic acid cycle highlighting its importance in energy metabolism.

Pathways

ACSF3 plays a significant role in fatty acid metabolism and energy production within cells. It participates in the fatty acid oxidation pathway where it helps in the activation and breakdown of fatty acids providing an essential fuel source for the body. ACSF3 is related to the protein CPT1A which is another key player in the fatty acid oxidation pathway facilitating the transport of fatty acids into mitochondria for oxidation.

ACSF3 is linked with combined malonic and methylmalonic aciduria a metabolic disorder characterized by the accumulation of malonic and methylmalonic acids in the body. Mutations in ACSF3 can disrupt normal enzyme function leading to this condition. Additionally ACSF3 has potential implications in lipid-related disorders and is examined in relation to proteins such as MUT whose deficiencies are also associated with methylmalonic aciduria.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester (PubMed : 21841779, PubMed : 21846720). May have some preference toward very-long-chain substrates (PubMed : 17762044).
See full target information ACSF3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Experimental physiology 109:562-575 PubMed38180279

2024

Postnatal growth restriction alters myocardial mitochondrial energetics in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Joseph R Visker,Eric C Leszczynski,Austin G Wellette-Hunsucker,Ashley C McPeek,Melissa A Quinn,Seong Hyun Kim,Jason N Bazil,David P Ferguson
View all publications
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