Anti-ACSM2A antibody [EPR13330-17]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ACSM2A also known as acyl-CoA synthetase medium-chain family member 2A is an enzyme that activates medium-chain fatty acids by converting them into acyl-CoA derivatives. It has a molecular mass of approximately 63 kDa. This enzyme expresses in liver and kidney tissues where it plays a significant role in lipid metabolism by facilitating the utilization of medium-chain fatty acids.

Biological function summary

ACSM2A catalyzes the formation of acyl-CoA from free fatty acids ATP and coenzyme A. It belongs to the acyl-CoA synthetase family which includes enzymes that are essential for fatty acid metabolism. While not explicitly part of a larger enzymatic complex ACSM2A interacts with other members of this family to modulate fatty acid activation and energy production.

Pathways

ACSM2A significantly contributes to beta-oxidation and the fatty acid metabolic process. It works closely with enzymes like CPT1A (carnitine palmitoyltransferase 1A) in the mitochondria to ensure efficient transport and oxidation of fatty acids. In these pathways ACSM2A's activity is vital for maintaining energy balance and regulating lipid levels within the cell.

Associated diseases and disorders

Mutations or dysregulations of ACSM2A may associate with metabolic conditions such as obesity and diabetes mellitus. Its connection to obesity involves interactions with proteins like PPARα (peroxisome proliferator-activated receptor alpha) which regulates lipid metabolism and energy homeostasis. Altered expressions of ACSM2A can impact these metabolic pathways influencing disease progression.