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AB89307

Anti-Activin A antibody [MM0074-7L18]

3

(3 Reviews)

|

(11 Publications)

Mouse Monoclonal Inhibin beta A antibody. Carrier free. Suitable for WB, FuncS (Neut/Block) and reacts with Rat, Human samples. Cited in 11 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Inhibin beta A chain.

View Alternative Names

Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein, EDF, INHBA

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

MM0074-7L18

Isotype

IgG1

Carrier free

Yes

Reacts with

Human, Rat

Applications

FuncS (Neut/Block), WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Inhibin beta A chain.

P08476

Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Activin A also known by its gene name INHBA is a protein involved in various mechanical processes in the human body. This protein forms part of the transforming growth factor-beta (TGF-β) superfamily and has a molecular weight of approximately 25 kDa for its dimeric forms. Activin A is expressed in many tissues including the pituitary gland reproductive organs and placenta. Researchers often use techniques like the Activin A ELISA test kit to measure its concentration in biological samples.
Biological function summary

Activin A plays a significant role in regulating cell differentiation proliferation and apoptosis. As part of a complex Activin A interacts with specific receptors on cell surfaces initiating intracellular signaling cascades that influence these vital processes. It acts as a growth factor in the reproductive system influencing follicle-stimulating hormone (FSH) secretion and is important in embryonic development and wound healing.

Pathways

Activin A participates in pathways such as the TGF-β signaling pathway and the SMAD protein signaling pathway. Within these pathways it interacts with receptor proteins like type I and type II Activin receptors and downstream SMAD proteins. These interactions enable Activin A to regulate gene expression relevant to various cellular functions.

Altered Activin A levels have associations with conditions like cancer and fibrotic diseases. Its overexpression links to some cancer types including colorectal and prostate cancer where it influences tumor growth and metastasis. Moreover its interaction with proteins like myostatin may contribute to muscle wasting disorders. The dysregulation of these pathways highlights the significance of Activin A in pathophysiology.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
See full target information Inhibin beta A chain

Publications (11)

Recent publications for all applications. Explore the full list and refine your search

International endodontic journal 58:991-1005 PubMed40106315

2025

Activin a regulates vascular formation and stabilization in direct coculture of dental pulp stem cells and endothelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jialin Zhong,Yuchen Zhang,Shulan Lin,Jun Kang,Mingxin Hu,Junqing Liu,Ying Chen,Qianzhou Jiang,Chengfei Zhang

Nature communications 16:2354 PubMed40064965

2025

Kallikrein-8 mediates furin-independent Activin-A precursor processing to stimulate tumor growth in melanoma.

Applications

Unspecified application

Species

Unspecified reactive species

Manon Bulliard,Katarina Pinjusic,Laura Iacobucci,Céline Schmuziger,Nadine Fournier,Daniel B Constam

Communications biology 7:1383 PubMed39448726

2024

Stepwise release of Activin-A from its inhibitory prodomain is modulated by cysteines and requires furin coexpression to promote melanoma growth.

Applications

Unspecified application

Species

Unspecified reactive species

Katarina Pinjusic,Manon Bulliard,Benjamin Rothé,Saeid Ansaryan,Yeng-Cheng Liu,Pierpaolo Ginefra,Céline Schmuziger,Hatice Altug,Daniel B Constam

Nature communications 15:4614 PubMed38816354

2024

ARID1B maintains mesenchymal stem cell quiescence via inhibition of BCL11B-mediated non-canonical Activin signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Mingyi Zhang,Tingwei Guo,Fei Pei,Jifan Feng,Junjun Jing,Jian Xu,Takahiko Yamada,Thach-Vu Ho,Jiahui Du,Prerna Sehgal,Yang Chai

Journal of neuroinflammation 20:50 PubMed36829205

2023

TREM2 mediates physical exercise-promoted neural functional recovery in rats with ischemic stroke via microglia-promoted white matter repair.

Applications

Unspecified application

Species

Unspecified reactive species

Jinghui Xu,Liying Zhang,Mingyue Li,Xiaofei He,Jing Luo,Rui Wu,Zhongqiu Hong,Haiqing Zheng,Xiquan Hu

World journal of clinical cases 10:2382-2392 PubMed35434072

2022

Analysis of bacterial spectrum, activin A, and CD64 in chronic obstructive pulmonary disease patients complicated with pulmonary infections.

Applications

Unspecified application

Species

Unspecified reactive species

Zhao-Yang Fei,Jiang Wang,Jie Liang,Xue Zhou,Min Guo

Neurochemical research 44:1807-1817 PubMed31093905

2019

Knockdown of microRNA-17-5p Enhances the Neuroprotective Effect of Act A/Smads Signal Loop After Ischemic Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Jiao-Qi Wang,Yue Dong,Si-Jia Li,Cheng-Liang Pan,Hong-Yu Liu,Yu-Kai Wang,Lei Xu,Jia-Hui Yang,Yun-Xia Cui,Jin-Ting He,Jing Mang,Zhong-Xin Xu

American journal of physiology. Heart and circulat 315:H1463-H1476 PubMed30141986

2018

Structural and functional cardiac profile after prolonged duration of mechanical unloading: potential implications for myocardial recovery.

Applications

Unspecified application

Species

Unspecified reactive species

Estibaliz Castillero,Ziad A Ali,Hirokazu Akashi,Nicholas Giangreco,Catherine Wang,Eric J Stöhr,Ruping Ji,Xiaokan Zhang,Nathaniel Kheysin,Joo-Eun S Park,Sheetal Hegde,Sanatkumar Patel,Samantha Stein,Carlos Cuenca,Diana Leung,Shunichi Homma,Nicholas P Tatonetti,Veli K Topkara,Koji Takeda,Paolo C Colombo,Yoshifumi Naka,H Lee Sweeney,P Christian Schulze,Isaac George

Reproductive sciences (Thousand Oaks, Calif.) 22:1597-602 PubMed26138721

2015

Expression Levels of Myostatin and Matrix Metalloproteinase 14 mRNAs in Uterine Leiomyoma are Correlated With Dysmenorrhea.

Applications

Unspecified application

Species

Unspecified reactive species

Anastasia Tsigkou,Fernando M Reis,Pasquapina Ciarmela,Meng H Lee,Bingjie Jiang,Claudia Tosti,Fang-Rong Shen,Zhendan Shi,You-Guo Chen,Felice Petraglia

PloS one 7:e37697 PubMed22685544

2012

BRCA1 regulates follistatin function in ovarian cancer and human ovarian surface epithelial cells.

Applications

WB

Species

Human

Tejaswita M Karve,Anju Preet,Rosie Sneed,Clara Salamanca,Xin Li,Jingwen Xu,Deepak Kumar,Eliot M Rosen,Tapas Saha
View all publications

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