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AB317379

Anti-Activin A Receptor Type IB/ALK-4 Antibody [S08-8D6]

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Rabbit Monoclonal Activin A Receptor Type IB/ALK-4 antibody. Suitable for WB, ICC/IF and reacts with Chinese hamster, Rat, Human samples. Immunogen corresponding to Synthetic Peptide within Human ACVR1B.

View Alternative Names

ACVRLK4, ALK4, ACVR1B, Activin receptor type-1B, Activin receptor type IB, Activin receptor-like kinase 4, Serine/threonine-protein kinase receptor R2, ACTR-IB, ALK-4, SKR2

2 Images
Western blot - Anti-Activin A Receptor Type IB/ALK-4 Antibody [S08-8D6] (AB317379)
  • WB

Supplier Data

Western blot - Anti-Activin A Receptor Type IB/ALK-4 Antibody [S08-8D6] (AB317379)

All lanes:

Western blot - Anti-Activin A Receptor Type IB/ALK-4 Antibody [S08-8D6] (ab317379) at 1/500 dilution

Lane 1:

CHO-K1 cell lysate

Lane 2:

Rat brain lysate

Predicted band size: 57 kDa

false

Immunocytochemistry/ Immunofluorescence - Anti-Activin A Receptor Type IB/ALK-4 Antibody [S08-8D6] (AB317379)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Activin A Receptor Type IB/ALK-4 Antibody [S08-8D6] (AB317379)

Immunofluorescence of Activin A Receptor Type IB/ALK-4 (green) in HeLa using ab317379 at dilution 1/50, and DAPI (blue).

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

S08-8D6

Isotype

IgG

Carrier free

No

Reacts with

Chinese hamster, Rat, Human

Applications

WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human ACVR1B.

P36896

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/20 - 1/50", "ICCIF-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Chinese hamster": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Storage buffer
pH: 7.4 Preservative: 0.01% Sodium azide Constituents: 55.08% Water, 40% Glycerol (glycerin, glycerine), 0.98% Tris glycine, 0.88% Sodium chloride, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Activin A Receptor Type IB also known as ACVR1B or ALK-4 is a serine/threonine kinase involved in the TGF-beta superfamily signaling. This receptor has a molecular mass of approximately 54 kDa and is expressed in a variety of tissues including the brain heart and reproductive organs. ALK-4 specifically interacts with type II activin receptors to mediate the signal transduction processes that are critical for cell differentiation and growth.
Biological function summary

ALK-4 plays an important role in cell differentiation proliferation and apoptosis. It forms a complex with activin type II receptors which is essential for its proper function. This receptor mediates the signaling pathways that regulate these cellular processes having a significant impact on development and tissue homeostasis. The action of ALK-4 is important for the regulation of mesodermal differentiation and the formation of the axial skeleton during embryogenesis.

Pathways

ALK-4 is part of the TGF-beta signaling pathway and the activin signaling pathway. These pathways are vital for various cellular processes including immune response and tissue repair. In the activin pathway ALK-4 functions along with its related proteins such as ACVR2A and SMAD2/3 to propagate the signal that induces gene expression changes. This signaling cascade involves phosphorylation events that eventually lead to the regulation of target gene expression in the nucleus.

ALK-4 has associations with reproductive disorders and cancer. Dysregulation of activin signaling involving ALK-4 can contribute to disorders such as polycystic ovary syndrome (PCOS) and has implications in tumor progression and metastasis in cancer. The receptor works closely with other proteins like inhibin and follistatin which modulate activin signaling highlighting its role in pathologies related to aberrant cell proliferation and differentiation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.
See full target information ACVR1B

Additional targets

Acvr1b,Acvr1b
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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